TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer.

TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer. Research Abstract Details 

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TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer. Abstract Text:

Sven Perner,Francesca Demichelis,Rameen Beroukhim,Folke H Schmidt,Juan-Miguel Mosquera,Sunita Setlur,Joelle Tchinda,Scott A Tomlins,Matthias D Hofer,Kenneth G Pienta,Rainer Kuefer,Robert Vessella,Xiao-Wei Sun,Matthew Meyerson,Charles Lee,William R Sellers,Arul M Chinnaiyan,Mark A Rubin,

Prostate cancer is a common and clinically heterogeneous disease with marked variability in progression. The recent identification of gene fusions of the 5'-untranslated region of TMPRSS2 (21q22.3) with the ETS transcription factor family members, either ERG (21q22.2), ETV1 (7p21.2), or ETV4 (17q21), suggests a mechanism for overexpression of the ETS genes in the majority of prostate cancers. In the current study using fluorescence in situ hybridization (FISH), we identified the TMPRSS2:ERG rearrangements in 49.2% of 118 primary prostate cancers and 41.2% of 18 hormone-naive lymph node metastases. The FISH assay detected intronic deletions between ERG and TMPRSS2 resulting in TMPRSS2:ERG fusion in 60.3% (35 of 58) of the primary TMPRSS2:ERG prostate cancers and 42.9% (3 of 7) of the TMPRSS2:ERG hormone-naive lymph node metastases. A significant association was observed between TMPRSS2:ERG rearranged tumors through deletions and higher tumor stage and the presence of metastatic disease involving pelvic lymph nodes. Using 100K oligonucleotide single nucleotide polymorphism arrays, a homogeneous deletion site between ERG and TMPRSS2 on chromosome 21q22.2-3 was identified with two distinct subclasses distinguished by the start point of the deletion at either 38.765 or 38.911 Mb. This study confirms that TMPRSS2:ERG is fused in approximately half of the prostate cancers through deletion of genomic DNA between ERG and TMPRSS2. The deletion as cause of TMPRSS2:ERG fusion is associated with clinical features for prostate cancer progression compared with tumors that lack the TMPRSS2:ERG rearrangement.

TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer. Publishing Authors By Initials

S Perner,F Demichelis,R Beroukhim,FH Schmidt,JM Mosquera,S Setlur,J Tchinda,SA Tomlins,MD Hofer,KG Pienta,R Kuefer,R Vessella,XW Sun,M Meyerson,C Lee,WR Sellers,AM Chinnaiyan,MA Rubin,

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TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cancer research

VOLUME: 66

Page Numbers: 8337-41

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ISSN: 1538-7445

DAY: 1

MONTH: Sep

YEAR: 2006

TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer. Information

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LANGUAGE: eng

NlmUniqueID: 2984705

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Grant and Affiliation Information for TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer.

AFFILIATION: Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, EBRC 442A, 221 Longwood Avenue, Boston, MA 02115-6110, USA.

Country: United States

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MEDLINETA: Cancer Res

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