Tissue vitamin E levels in newborn rabbits after pharmacologic dosing. Influence of dose, dosage form, and route of administration.

Tissue vitamin E levels in newborn rabbits after pharmacologic dosing. Influence of dose, dosage form, and route of administration. Research Abstract Details 

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Tissue vitamin E levels in newborn rabbits after pharmacologic dosing. Influence of dose, dosage form, and route of administration. Abstract Text:

M E Knight,R J Roberts,

Tissue levels of alpha-tocopherol and alpha-tocopheryl acetate were measured in neonatal rabbits using high-performance liquid chromatography after administration of 100 mg/kg once or daily of either alpha-tocopherol or alpha-tocopheryl acetate subcutaneously, orally, or intravenously. Tissues were analyzed at 1, 3, and 6 days after daily dosing was begun. Tissue levels of alpha-tocopherol increased after each dose of alpha-tocopherol; the liver had much higher concentrations than other tissues after subcutaneous or oral administration. Alpha-tocopherol and alpha-tocopheryl acetate given orally produced similar tissue levels of alpha-tocopherol. Intravenous administration of alpha-tocopherol resulted in high concentrations of alpha-tocopherol in the liver, whereas intravenously administered alpha-tocopheryl acetate produced high concentrations of alpha-tocopheryl acetate in the lung. Following intravenous administration of alpha-tocopheryl acetate, only 2-4% of the total vitamin E present in the lung was alpha-tocopherol. From these results we conclude that total dose, dosage form, and route of administration of vitamin E have major influences on tissue vitamin E levels and whether the predominant molecular form is alpha-tocopherol or alpha-tocopheryl acetate. Assuming vitamin E tissue levels and molecular form determine tissue antioxidant activity, total dose, dosage form, and route of administration of vitamin E affect the potential clinical benefits that may result from pharmacologic vitamin E therapy in newborn infants.

Tissue vitamin E levels in newborn rabbits after pharmacologic dosing. Influence of dose, dosage form, and route of administration. Publishing Authors By Initials

ME Knight,RJ Roberts,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research

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Tissue vitamin E levels in newborn rabbits after pharmacologic dosing. Influence of dose, dosage form, and route of administration. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Developmental pharmacology and therapeutics

VOLUME: 8

Page Numbers: 96-106

Journal Abbreviation:

ISSN: 0379-8305

DAY: 19

MONTH: 11

YEAR: 1985

Tissue vitamin E levels in newborn rabbits after pharmacologic dosing. Influence of dose, dosage form, and route of administration. Information

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LANGUAGE: eng

NlmUniqueID: 8003947

Tissue vitamin E levels in newborn rabbits after pharmacologic dosing. Influence of dose, dosage form, and route of administration. Keywords Mesh Terms:

KEYWORDS: alpha-Tocopherol

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Tissue vitamin E levels in newborn rabbits after pharmacologic dosing. Influence of dose, dosage form, and route of administration. Information

Substance Name: tocopherol acetate

Registry Number: 7695-91-2

Grant and Affiliation Information for Tissue vitamin E levels in newborn rabbits after pharmacologic dosing. Influence of dose, dosage form, and route of administration.

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Country: SWITZERLAND

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MEDLINETA: Dev Pharmacol Ther

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