Tissue-specific regulation of renin-binding protein gene expression in rats.

Tissue-specific regulation of renin-binding protein gene expression in rats. Research Abstract Details 

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Tissue-specific regulation of renin-binding protein gene expression in rats. Abstract Text:

M Tada,S Takahashi,M Miyano,Y Miyake,

Rat gene for renin-binding protein (RnBP) was shown to be expressed in the kidney, adrenal gland, brain, lung, spleen, ovary, testis, and heart. On sodium depletion and captopril administration, the rat showed a marked increase in the adrenal RnBP mRNA level and a slight decrease in the kidney RnBP mRNA level. In two-kidney, one clip hypertensive rats, the RnBP mRNA levels of the clipped and contralateral kidneys were unchanged and also its adrenal mRNA level was maintained at the control level. The recombinant rat RnBP was synthesized in Escherichia coli cells and purified to apparent homogeneity. The RnBP existed as a homodimer and formed a heterodimer with rat renin to inhibit renin activity extensively. Intravenous injection of the RnBP into rats resulted in a rapid and strong inhibition of plasma renin activity, which persisted at least for 2 h. These results suggest that the expression of RnBP gene in the kidney and adrenal gland is regulated independently, and the function of RnBP is related to electrolyte homeostasis, probably through the interaction with renin.

Tissue-specific regulation of renin-binding protein gene expression in rats. Publishing Authors By Initials

M Tada,S Takahashi,M Miyano,Y Miyake,

For similar inorganic chemicals: elements: metals, alkali: sodium research abstracts see: inorganic chemicals: elements: metals, alkali: sodium research

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Tissue-specific regulation of renin-binding protein gene expression in rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 112

Page Numbers: 175-82

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Aug

YEAR: 1992

Tissue-specific regulation of renin-binding protein gene expression in rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376600

Tissue-specific regulation of renin-binding protein gene expression in rats. Keywords Mesh Terms:

KEYWORDS: Sodium

MESH TERMS: metabolism

Chemical & Substance for Abstract: Tissue-specific regulation of renin-binding protein gene expression in rats. Information

Substance Name: Renbp protein, rat

Registry Number: EC 5.1.3.8

Grant and Affiliation Information for Tissue-specific regulation of renin-binding protein gene expression in rats.

AFFILIATION: Department of Biochemistry, National Cardiovascular Center Research Institute, Osaka.

Country: JAPAN

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MEDLINETA: J Biochem

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