In this report we have examined two new heat shock protein (HSP16) proteins in the nematode Caenorhabditis elegans encoded by the open reading frames F08H9.3 and F08H9.4. The F08H9.3 and F08H9.4 genes are oriented in the same direction next to each other on the chromosome, not sharing any promoter region, unlike other hsp16 genes that share common promoters in pairs. The F08H9.3 and F08H9.4 proteins were expressed in a tissue-specific manner, unlike the other four HSP16 proteins. F08H9.3 was expressed in the pharynx, and F08H9.4 in the excretory canal and a few neuronal cells. While F08H9.3 was weakly induced by heat shock only in the same tissue as under the normal condition, F08H9.4 was newly induced in the intestine. RNA interference experiments showed that these two proteins are required for survival under the heat shock condition.
Tissue-specific expression, heat inducibility, and biological roles of two hsp16 genes in Caenorhabditis elegans. Publishing Authors By Initials
Tissue-specific expression, heat inducibility, and biological roles of two hsp16 genes in Caenorhabditis elegans. Journal Published:
PUBLICATION TYPE: Research Support, Non-U.S. Gov
Journal: FEBS letters
VOLUME: 537
Page Numbers: 139-45
Journal Abbreviation: FEBS Lett.
ISSN: 0014-5793
DAY: 27
MONTH: Feb
YEAR: 2003
Tissue-specific expression, heat inducibility, and biological roles of two hsp16 genes in Caenorhabditis elegans. Information
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LANGUAGE: eng
NlmUniqueID: 155157
Tissue-specific expression, heat inducibility, and biological roles of two hsp16 genes in Caenorhabditis elegans. Keywords Mesh Terms:
KEYWORDS: Sequence Homology, Amino Acid
MESH TERMS: physiology
Chemical & Substance for Abstract: Tissue-specific expression, heat inducibility, and biological roles of two hsp16 genes in Caenorhabditis elegans. Information
Substance Name: Protein Isoforms
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Grant and Affiliation Information for Tissue-specific expression, heat inducibility, and biological roles of two hsp16 genes in Caenorhabditis elegans.
AFFILIATION: National Research Laboratory, Department of Biology, Yonsei University, 134 Shinchon-dong, Seoul 120-749, South Korea.
Country: Netherlands
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MEDLINETA: FEBS Lett
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