Tissue-specific effects of central leptin on the expression of genes involved in lipid metabolism in liver and white adipose tissue.

Tissue-specific effects of central leptin on the expression of genes involved in lipid metabolism in liver and white adipose tissue. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Tissue-specific effects of central leptin on the expression of genes involved in lipid metabolism in liver and white adipose tissue. Abstract Text:

Nilda Gallardo,Elena ,Teresa ,Eduardo ,Sergio ,Pablo Blanco,Jose Ma Carrascosa,Manuel Ros,Antonio ,Nilda Gallardo,Elena ,Teresa ,Eduardo ,Sergio ,Pablo Blanco,Jose Maria Carrascosa,Manuel Ros,Antonio ,

Leptin reduces adiposity and exerts antisteatotic effects on nonadipose tissues. However, the mechanisms underlying leptin effects on lipid metabolism in liver and white adipose tissue have not been fully clarified. Here, we have studied the effects of central leptin administration on key enzymes and transcription factors involved in lipid metabolism in liver and epididymal adipose tissue. Intracerebroventricular leptin infusion for 7 d did not change leptin plasma levels but decreased triacylglyceride content in liver, epididymal adipose tissue, and plasma. In both tissues this treatment markedly decreased the expression of key enzymes of the de novo fatty acid (FA) synthesis such as acetyl-coenzyme A-carboxylase, FA synthase, and stearoyl-coenzyme A desaturase-1, in parallel with a reduction in mRNA expression of sterol regulatory element binding protein-1c in liver and carbohydrate regulatory element binding protein in adipose tissue. In addition, leptin also decreased phosphoenol-pyruvate carboxykinase-C expression in adipose tissue, an enzyme involved in glyceroneogenesis in this tissue. Central leptin administration down-regulates delta-6-desaturase expression in liver and adipose tissue, in parallel with the decrease of the expression of sterol regulatory element binding protein-1c in liver and peroxisome proliferator activated receptor alpha in adipose tissue. Finally, leptin treatment, by regulating adipose triglyceride lipase/hormone sensitive lipase/diacylglycerol transferase 1 expression, also established a new partitioning in the FA-triacylglyceride cycling in adipose tissue, increasing lipolysis and probably the FA efflux from this tissue, and favoring in parallel the FA uptake and oxidation in the liver. These results suggest that leptin, acting at central level, exerts tissue-specific effects in limiting fat tissue mass and lipid accumulation in nonadipose tissues, preventing the development of obesity and type 2 diabetes.

Tissue-specific effects of central leptin on the expression of genes involved in lipid metabolism in liver and white adipose tissue. Publishing Authors By Initials

N Gallardo,E ,T ,E ,S ,P Blanco,JM Carrascosa,M Ros,A ,N Gallardo,E ,T ,E ,S ,P Blanco,JM Carrascosa,M Ros,A ,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Tissue-specific effects of central leptin on the expression of genes involved in lipid metabolism in liver and white adipose tissue. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Endocrinology

VOLUME: 148

Page Numbers: 5604-10

Journal Abbreviation: Endocrinology

ISSN: 0013-7227

DAY: 6

MONTH: 09

YEAR: 2007

Tissue-specific effects of central leptin on the expression of genes involved in lipid metabolism in liver and white adipose tissue. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375040

Tissue-specific effects of central leptin on the expression of genes involved in lipid metabolism in liver and white adipose tissue. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Tissue-specific effects of central leptin on the expression of genes involved in lipid metabolism in liver and white adipose tissue. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Tissue-specific effects of central leptin on the expression of genes involved in lipid metabolism in liver and white adipose tissue.

AFFILIATION: Area de Bioquímica, Facultad de Químicas, Regional Centre for Biomedical Research, Avda. Camilo José Cela, 10, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain. antonio.andres@uclm.es.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Endocrinology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Tissue-specific effects of central leptin on the expression of genes involved in lipid metabolism in liver and white adipose tissue Related Publications

• A Theoretical Study on the Electronic Structure of Au-XO((0,-1,+1)) (X = C, N, and O) Complexes: Effect of an External Electric Field.
• A novel cyclic AMP-dependent Epac-Rit signaling pathway contributes to PACAP38-mediated neuronal differentiation.
• Aggressive form of multiple myeloma presenting with specific pleural effusion, neutrophilia, and eosinophilia.
• Ambiguity function analysis of pulse train propagation: applications to temporal Lau filtering.
• Broadband space-variant Fresnel processor.
• Faut-il circoncire les nouveau-nes?: NON.
• Focal-shift formula in apodized nontelecentric focusing systems.
• Full-vector analysis of a realistic photonic crystal fiber.
• Increased locomotor response to amphetamine induced by the repeated administration of the selective kappa-opioid receptor agonist U-69593.
• Increased p53 gene dosage reduces neointimal thickening induced by mechanical injury but has no effect on native atherosclerosis.
• Nearly zero ultraflattened dispersion in photonic crystal fibers.
• Optical security and encryption with totally incoherent light.
• Parvovirus B19 infection as a cause of cytopenia with a lupus-like presentation in the elderly: A case report.
• Plasma membrane targeting is essential for Rem-mediated Ca2+ channel inhibition.
• Prevention of clinical mastitis with barium selenate in dairy goats from a selenium-deficient area.
• Proliferation and apoptosis in mammary epithelium during the rat oestrous cycle.
• Rebuttal: Should newborns be circumcised?: NO.
• Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction.
• Sexual dimorphism and the genetic potential for evolution of sex allocation in the gynodioecious plant, Schiedea salicaria.
• Should newborns be circumcised?: NO.
• Spectral imaging system for scaling the power spectrum of optical waveforms.
• Telomere dysfunction in hypertension.
• The RGK family of GTP-binding proteins: Regulators of voltage-dependent calcium channels and cytoskeleton remodeling.
• The novel GTPase Rit differentially regulates axonal and dendritic growth.
• Tissue-specific effects of central leptin on the expression of genes involved in lipid metabolism in liver and white adipose tissue.
• Transmission disequilibrium study of an oligodendrocyte and myelin glycoprotein gene allele in 431 families with an autistic proband.
• Universal alternating order around impurities in antiferromagnets.
• Wavelength-compensated Fourier and Fresnel transformers: a unified approach.
• [Not Available.]
• [Recurrent acute fatty liver of pregnancy.]