Tissue distribution of cynomolgus adeno-associated viruses AAV10, AAV11, and AAVcy.7 in naturally infected monkeys.

Tissue distribution of cynomolgus adeno-associated viruses AAV10, AAV11, and AAVcy.7 in naturally infected monkeys. Research Abstract Details 

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Tissue distribution of cynomolgus adeno-associated viruses AAV10, AAV11, and AAVcy.7 in naturally infected monkeys. Abstract Text:

S Mori,T Takeuchi,Y Enomoto,K Kondo,K Sato,F Ono,T Sata,T Kanda,S Mori,T Takeuchi,Y Enomoto,K Kondo,K Sato,F Ono,T Sata,T Kanda,

Adeno-associated virus (AAV) is used in gene-therapy studies, but its tissue distribution is unknown in natural infection. We examined cynomolgus AAVs (previously isolated AAV10 and AAV11 and novel AAVcy.7) for their tissue distribution in 14 cynomolgi by type-specific PCR. We found AAV10, AAV11, and AAVcy.7 in 6, 10, and 14 monkeys, respectively, and two or three types in 11 monkeys, showing that these AAVs are widespread in the monkeys. We detected AAV at a higher level mainly in the lymphatic tissues and ileum, which suggests that AAV may invade the host through Peyer's patches in the ileum and infect immune cells.

Tissue distribution of cynomolgus adeno-associated viruses AAV10, AAV11, and AAVcy.7 in naturally infected monkeys. Publishing Authors By Initials

S Mori,T Takeuchi,Y Enomoto,K Kondo,K Sato,F Ono,T Sata,T Kanda,S Mori,T Takeuchi,Y Enomoto,K Kondo,K Sato,F Ono,T Sata,T Kanda,

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Tissue distribution of cynomolgus adeno-associated viruses AAV10, AAV11, and AAVcy.7 in naturally infected monkeys. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of virology

VOLUME: 153

Page Numbers: 375-80

Journal Abbreviation: Arch. Virol.

ISSN: 0304-8608

DAY: 10

MONTH: 12

YEAR: 2007

Tissue distribution of cynomolgus adeno-associated viruses AAV10, AAV11, and AAVcy.7 in naturally infected monkeys. Information

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LANGUAGE: eng

NlmUniqueID: 7506870

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AFFILIATION: Center for Pathogen Genomics, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan.

Country: Austria

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MEDLINETA: Arch Virol

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