Timing of menarche and first full-term birth in relation to breast cancer risk.

Timing of menarche and first full-term birth in relation to breast cancer risk. Research Abstract Details 

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Timing of menarche and first full-term birth in relation to breast cancer risk. Abstract Text:

Christopher I Li,Kathleen E Malone,Janet R Daling,John D Potter,Leslie Bernstein,Polly A Marchbanks,Brian L Strom,Michael S Simon,Michael F Press,Giske Ursin,Ronald T Burkman,Suzanne G Folger,Sandra Norman,Jill A McDonald,Robert Spirtas,Christopher I Li,Kathleen E Malone,Janet R Daling,John D Potter,Leslie Bernstein,Polly A Marchbanks,Brian L Strom,Michael S Simon,Michael F Press,Giske Ursin,Ronald T Burkman,Suzanne G Folger,Sandra Norman,Jill A McDonald,Robert Spirtas,

Ages at menarche and first birth are established risk factors for breast cancer. The interval between these ages may also affect risk, since the breast is more susceptible to carcinogenic insults during this period than during the parous period. However, few investigators have studied this relation. Using logistic regression, the authors evaluated associations between the timing of reproductive events and breast cancer risk among 4,013 cases and 4,069 controls enrolled in a multicenter, population-based US case-control study of White and African-American women (1994-1998). For White, parous premenopausal and postmenopausal women, those who had an interval of > or =16 years between the ages of menarche and first birth had 1.5-fold (95% confidence interval (CI): 1.0, 2.2) and 1.4-fold (95% CI: 1.1, 1.8) increased risks of breast cancer, respectively, in comparison with those who had < or =5 years between these ages. Adjusting for age at first birth altered these risk estimates somewhat, to odds ratios of 1.5 (95% CI: 0.8, 2.9) and 1.0 (95% CI: 0.6, 1.5), respectively. These associations were stronger for lobular and hormone-receptor-positive tumors but were absent among premenopausal African-American women. The authors conclude that the interval between age at menarche and age at first birth is associated with the risk of hormonally sensitive types of breast cancer, particularly among White women.

Timing of menarche and first full-term birth in relation to breast cancer risk. Publishing Authors By Initials

CI Li,KE Malone,JR Daling,JD Potter,L Bernstein,PA Marchbanks,BL Strom,MS Simon,MF Press,G Ursin,RT Burkman,SG Folger,S Norman,JA McDonald,R Spirtas,CI Li,KE Malone,JR Daling,JD Potter,L Bernstein,PA Marchbanks,BL Strom,MS Simon,MF Press,G Ursin,RT Burkman,SG Folger,S Norman,JA McDonald,R Spirtas,

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Timing of menarche and first full-term birth in relation to breast cancer risk. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: American journal of epidemiology

VOLUME: 167

Page Numbers: 230-9

Journal Abbreviation: Am. J. Epidemiol.

ISSN: 1476-6256

DAY: 26

MONTH: 10

YEAR: 2007

Timing of menarche and first full-term birth in relation to breast cancer risk. Information

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LANGUAGE: eng

NlmUniqueID: 7910653

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Grant and Affiliation Information for Timing of menarche and first full-term birth in relation to breast cancer risk.

AFFILIATION: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. cili@fhcrc.org

Country: United States

AGENCY: United States NICHD

GRANT: Y01-HD-7022

ACRONYM: HD

MEDLINETA: Am J Epidemiol

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