Timing and value of protocol biopsies in well-matched kidney transplant recipients--a clinical and histopathologic analysis.

Timing and value of protocol biopsies in well-matched kidney transplant recipients--a clinical and histopathologic analysis. Research Abstract Details 

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Timing and value of protocol biopsies in well-matched kidney transplant recipients--a clinical and histopathologic analysis. Abstract Text:

Ilkka ,Fernanda Ortiz,Heikki Helin,Anne ,Eero Honkanen,Petri Koskinen,Ilkka ,Fernanda Ortiz,Heikki Helin,Anne ,Eero Honkanen,Petri Koskinen,Ilkka ,Fernanda Ortiz,Heikki Helin,Anne ,Eero Honkanen,Petri Koskinen,

The role and timing of protocol biopsies after kidney transplantation are controversial. We changed our protocol biopsy policy and compared the predictive value of biopsies at different time-points. Protocol biopsies at 6 months (n = 45) were obtained during 2001-2004, and at 3 and 12 months from 2004 (n = 41). Donor biopsy was available from 70 patients. Histopathologic changes were described with chronic allograft damage index (CADI) and Banff 1997. Follow-up was for 18 months. Chronic allograft nephropathy (CAN) was present in 12%, 51%, and 34% and borderline or subclinical rejection in 9.8%, 8.9%, and 7.3% of patients at 3, 6, and 12 months. CAN at 6 and 12 months was associated with reduced graft function (P = 0.001). Semiquantitative CADI scores at all time-points significantly correlated with glomerular filtration rate (GFR) at 18 months. Strongest correlation existed with CADI at 12 months (P < 0.001). Change in CADI between 0-6 and 0-12 months, but not between 0-3 and 3-12 months, correlated with GFR at 18 months (P = 0.03, P = 0.01). Subclinical rejections were rare and chronic changes mild at 3 months. In our well-matched population, the predictive value of a biopsy at 3 months was inferior to biopsies at 6 or 12 months, both of which were effective in predicting long-term graft function.

Timing and value of protocol biopsies in well-matched kidney transplant recipients--a clinical and histopathologic analysis. Publishing Authors By Initials

I ,F Ortiz,H Helin,A ,E Honkanen,P Koskinen,I ,F Ortiz,H Helin,A ,E Honkanen,P Koskinen,I ,F Ortiz,H Helin,A ,E Honkanen,P Koskinen,

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Timing and value of protocol biopsies in well-matched kidney transplant recipients--a clinical and histopathologic analysis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Transplant international : official journal of the

VOLUME: 20

Page Numbers: 982-90

Journal Abbreviation: Transpl. Int.

ISSN: 0934-0874

DAY: 10

MONTH: Nov

YEAR: 2007

Timing and value of protocol biopsies in well-matched kidney transplant recipients--a clinical and histopathologic analysis. Information

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LANGUAGE: eng

NlmUniqueID: 8908516

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Grant and Affiliation Information for Timing and value of protocol biopsies in well-matched kidney transplant recipients--a clinical and histopathologic analysis.

AFFILIATION: Department of Medicine, Division of Nephrology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. ilkka.helantera@helsinki.fi

Country: Germany

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MEDLINETA: Transpl Int

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