Timing and location of synaptic inputs determine modes of subthreshold integration in striatal medium spiny neurons.

Timing and location of synaptic inputs determine modes of subthreshold integration in striatal medium spiny neurons. Research Abstract Details 

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Timing and location of synaptic inputs determine modes of subthreshold integration in striatal medium spiny neurons. Abstract Text:

Adam G Carter,Gilberto J Soler-Llavina,Bernardo L Sabatini,

Medium spiny neurons (MSNs) are the principal cells of the striatum and perform a central role in sensorimotor processing. MSNs must integrate many excitatory inputs located across their dendrites to fire action potentials and enable striatal function. However, the dependence of synaptic responses on the temporal and spatial distribution of these inputs remains unknown. Here, we use whole-cell recordings, two-photon microscopy, and two-photon glutamate uncaging to examine subthreshold synaptic integration in MSNs from acute rat brain slices. We find that synaptic responses can summate sublinearly, linearly, or supralinearly depending on the spatiotemporal pattern of activity. Repetitive activity at single inputs leads to sublinear summation, reflecting long-lived AMPA receptor desensitization. In contrast, asynchronous activity at multiple inputs generates linear summation, with synapses on neighboring spines functioning independently. Finally, synchronous activity at multiple inputs triggers supralinear summation at depolarized potentials, reflecting activation of NMDA receptors and L-type calcium channels. Thus, the properties of subthreshold integration in MSNs are determined by the distribution of synaptic inputs and the differential activation of multiple postsynaptic conductances.

Timing and location of synaptic inputs determine modes of subthreshold integration in striatal medium spiny neurons. Publishing Authors By Initials

AG Carter,GJ Soler-Llavina,BL Sabatini,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

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Timing and location of synaptic inputs determine modes of subthreshold integration in striatal medium spiny neurons. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of neuroscience : the official journal

VOLUME: 27

Page Numbers: 8967-77

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 15

MONTH: Aug

YEAR: 2007

Timing and location of synaptic inputs determine modes of subthreshold integration in striatal medium spiny neurons. Information

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LANGUAGE: eng

NlmUniqueID: 8102140

Timing and location of synaptic inputs determine modes of subthreshold integration in striatal medium spiny neurons. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: radiation effects

Chemical & Substance for Abstract: Timing and location of synaptic inputs determine modes of subthreshold integration in striatal medium spiny neurons. Information

Substance Name: Calcium

Registry Number: 7440-70-2

Grant and Affiliation Information for Timing and location of synaptic inputs determine modes of subthreshold integration in striatal medium spiny neurons.

AFFILIATION: Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS046579-01A

ACRONYM: NS

MEDLINETA: J Neurosci

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