Time to first flare-up episode of GVHD can stratify patients according to their prognosis during clinical course of progressive- or quiescent-type chronic GVHD.

Time to first flare-up episode of GVHD can stratify patients according to their prognosis during clinical course of progressive- or quiescent-type chronic GVHD. Research Abstract Details 

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Time to first flare-up episode of GVHD can stratify patients according to their prognosis during clinical course of progressive- or quiescent-type chronic GVHD. Abstract Text:

D H Kim,S K Sohn,J H Baek,K-H Lee,J-H Lee,S-J Choi,I-H Shin,D H Kim,S K Sohn,J H Baek,K-H Lee,J-H Lee,S-J Choi,I-H Shin,

GVHD-specific survival (GSS) has been investigated as a potential study end point to describe the clinical course and outcome of chronic GVHD (cGVHD). However, reaching this end point requires a long observation time. We hypothesized that the time to the first flare-up (FFU) of cGVHD (TTF) can be an alternative statistical end point to GSS. This retrospective study included 96 patients with a diagnosis of cGVHD from a cohort of 119 patients with a prior history of acute GVHD. The median TTF was 73 days after the diagnosis of cGVHD. The 2-year cumulative incidences of first, second and third episodes of flare-up (FU) during courses of cGVHD were estimated as 69.5, 46.4 and 22.1%. Those patients who did not have an episode of FU of cGVHD had 96.0% of 2-years GSS rate, while those with 1 and > or =2 episodes had 50.8 and 46.8%, respectively (P=0.001). Shorter TTF was associated with poor GSS and decreased overall survival. The shorter TTF during the course of cGVHD was significantly associated with extensive cGVHD (P=0.002), Hopkins' risk category (P=0.022) and progressive-type cGVHD (P<0.001) in multivariate analysis. We propose that TTF can be an alternative end point to GSS in cGVHD trials.

Time to first flare-up episode of GVHD can stratify patients according to their prognosis during clinical course of progressive- or quiescent-type chronic GVHD. Publishing Authors By Initials

DH Kim,SK Sohn,JH Baek,KH Lee,JH Lee,SJ Choi,IH Shin,DH Kim,SK Sohn,JH Baek,KH Lee,JH Lee,SJ Choi,IH Shin,

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Time to first flare-up episode of GVHD can stratify patients according to their prognosis during clinical course of progressive- or quiescent-type chronic GVHD. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bone marrow transplantation

VOLUME: 40

Page Numbers: 779-84

Journal Abbreviation: Bone Marrow Transplant.

ISSN: 0268-3369

DAY: 13

MONTH: 08

YEAR: 2007

Time to first flare-up episode of GVHD can stratify patients according to their prognosis during clinical course of progressive- or quiescent-type chronic GVHD. Information

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LANGUAGE: eng

NlmUniqueID: 8702459

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AFFILIATION: Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu, Korea. drkiim@medimail.co.kr

Country: England

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MEDLINETA: Bone Marrow Transplant

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