Time-dependent response of vestibular hair cells of guinea pigs following high-dose applications of streptomycin.

Time-dependent response of vestibular hair cells of guinea pigs following high-dose applications of streptomycin. Research Abstract Details 

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Time-dependent response of vestibular hair cells of guinea pigs following high-dose applications of streptomycin. Abstract Text:

T Nakagawa,H Yamane,M Takayama,K Sunami,Y Nakai,

Apoptosis has been reported to occur in vestibular hair cells following aminoglycoside treatment and is suggested to play a predominant role in deletion of affected hair cells. However, the type of cell death occurring during an acute phase of vestibular damage following high-dose application of streptomycin has not yet been determined. Hence, in this study we examined the cell death mode of vestibular hair cells during the acute phase. The numbers of hair cell nuclei stained by the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labelling (TUNEL) method and residual hair cells were quantitatively analysed. Hoechst nuclear staining was used for analysis of the nuclear morphology of affected hair cells. TUNEL staining of hair cell nuclei and lost hair cells began to appear 6 h after streptomycin treatment and increased with more exposure time. Apoptotic nuclear features could also be found from 6 h after streptomycin treatment. These findings support the thesis that apoptosis is a predominant cell death mode in degeneration of vestibular hair cells due to streptomycin ototoxicity.

Time-dependent response of vestibular hair cells of guinea pigs following high-dose applications of streptomycin. Publishing Authors By Initials

T Nakagawa,H Yamane,M Takayama,K Sunami,Y Nakai,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Time-dependent response of vestibular hair cells of guinea pigs following high-dose applications of streptomycin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta oto-laryngologica. Supplementum

VOLUME: 538

Page Numbers: 32-5

Journal Abbreviation:

ISSN: 0365-5237

DAY: 13

MONTH: 02

YEAR: 1998

Time-dependent response of vestibular hair cells of guinea pigs following high-dose applications of streptomycin. Information

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LANGUAGE: eng

NlmUniqueID: 370355

Time-dependent response of vestibular hair cells of guinea pigs following high-dose applications of streptomycin. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: toxicity

Chemical & Substance for Abstract: Time-dependent response of vestibular hair cells of guinea pigs following high-dose applications of streptomycin. Information

Substance Name: Streptomycin

Registry Number: 57-92-1

Grant and Affiliation Information for Time-dependent response of vestibular hair cells of guinea pigs following high-dose applications of streptomycin.

AFFILIATION: Department of Otorhinolaryngology, Yodogawa Christian Hospital, Japan.

Country: NORWAY

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MEDLINETA: Acta Otolaryngol Suppl

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