Time course of hypoxia-induced lung injury in rats.

Time course of hypoxia-induced lung injury in rats. Research Abstract Details 

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Time course of hypoxia-induced lung injury in rats. Abstract Text:

Beate Rassler,Grit Marx,Christian Reissig,Marc A Rohling,Andrea Tannapfel,Roland H Wenger,Heinz-Gerd Zimmer,Beate Rassler,Grit Marx,Christian Reissig,Marc A Rohling,Andrea Tannapfel,Roland H Wenger,Heinz-Gerd Zimmer,

We investigated the effects of normobaric hypoxia on rat lungs and hypothesized that the hypoxic exposure would induce lung injury with pulmonary edema and inflammation ensued by development of fibrosis. Rats were exposed to 10% O(2) in nitrogen over 6-168h. We analyzed cardiovascular function and pulmonary changes, lung histology and mRNA expression of extracellular matrix (ECM) molecules in the lung. Significant hemodynamic changes occurred after 168h of hypoxic exposure. Moderate pulmonary edema appeared after 8h and peaked after 16h of hypoxia. It was accompanied by inflammation, fibrosis and vascular hypertrophy. mRNA expression of transforming growth factor-beta2 and -beta3 was up-regulated in lung tissue after 8h of hypoxia. After 8-16h, mRNA expression of collagen types I and III and of other ECM molecules was significantly elevated and increased further with longer exposure to hypoxia. The time course of hypoxia-induced pulmonary injury resembled that previously observed after continuous norepinephrine infusion in rats.

Time course of hypoxia-induced lung injury in rats. Publishing Authors By Initials

B Rassler,G Marx,C Reissig,MA Rohling,A Tannapfel,RH Wenger,HG Zimmer,B Rassler,G Marx,C Reissig,MA Rohling,A Tannapfel,RH Wenger,HG Zimmer,

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Time course of hypoxia-induced lung injury in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Respiratory physiology & neurobiology

VOLUME: 159

Page Numbers: 45-54

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ISSN: 1569-9048

DAY: 18

MONTH: 05

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Carl-Ludwig-Institute of Physiology, University of Leipzig, Liebigstr. 27, D-04103 Leipzig, Germany. rasb@medizin.uni-leipzig.de

Country: Netherlands

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MEDLINETA: Respir Physiol Neurobiol

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