Tight and adherens junctions in the ovine uterus: differential regulation by pregnancy and progesterone.

Tight and adherens junctions in the ovine uterus: differential regulation by pregnancy and progesterone. Research Abstract Details 

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Tight and adherens junctions in the ovine uterus: differential regulation by pregnancy and progesterone. Abstract Text:

M Carey Satterfield,Kathrin A Dunlap,Kanako Hayashi,Robert C Burghardt,Thomas E Spencer,Fuller W Bazer,

In species with noninvasive implantation by conceptus trophectoderm, fetal/maternal communications occur across the endometrial epithelia. The present studies identified changes in junctional complexes in the ovine endometrium that regulate paracellular trafficking of water, ions, and other molecules, and the secretory capacity of the uterine epithelia. Distinct temporal and spatial alterations in occludin, tight junction protein 2, and claudin 1-4 proteins were observed in the endometrium of cyclic and early pregnant ewes. Dynamic changes in tight junction formation were characterized by an abundance of tight junction proteins on d 10 of the estrous cycle and pregnancy that substantially decreased by d 12. Early progesterone administration advanced conceptus development on d 9 and 12 that was associated with loss of tight-junction-associated proteins. Pregnancy increased tight-junction-associated proteins between d 14-16. Cadherin 1 and beta-catenin, which form adherens junctions, were abundant in the endometrial glands, but decreased after d 10 of pregnancy in the luminal epithelium and then increased by d 16 with the onset of implantation. Results support the ideas that progesterone elicits transient decreases in tight and adherens junctions in the endometrial luminal epithelium between d 10-12 that increases selective serum and tissue fluid transudation to enhance blastocyst elongation, which is subsequently followed by an increase in tight and adherens junctions between d 14-16 that may be required for attachment and adherence of the trophectoderm for implantation. The continuous presence of tight and adherens junctions in the uterine glands would allow for vectorial secretion of trophic substances required for conceptus elongation and survival.

Tight and adherens junctions in the ovine uterus: differential regulation by pregnancy and progesterone. Publishing Authors By Initials

MC Satterfield,KA Dunlap,K Hayashi,RC Burghardt,TE Spencer,FW Bazer,

For similar proteins: armadillo domain proteins: beta catenin research abstracts see: proteins: armadillo domain proteins: beta catenin research

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Tight and adherens junctions in the ovine uterus: differential regulation by pregnancy and progesterone. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Endocrinology

VOLUME: 148

Page Numbers: 3922-31

Journal Abbreviation: Endocrinology

ISSN: 0013-7227

DAY: 3

MONTH: 05

YEAR: 2007

Tight and adherens junctions in the ovine uterus: differential regulation by pregnancy and progesterone. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375040

Tight and adherens junctions in the ovine uterus: differential regulation by pregnancy and progesterone. Keywords Mesh Terms:

KEYWORDS: beta Catenin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Tight and adherens junctions in the ovine uterus: differential regulation by pregnancy and progesterone. Information

Substance Name: Progesterone

Registry Number: 57-83-0

Grant and Affiliation Information for Tight and adherens junctions in the ovine uterus: differential regulation by pregnancy and progesterone.

AFFILIATION: Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A&M University, College Station, Texas 77843-2471, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: 5 P30 ES09106

ACRONYM: ES

MEDLINETA: Endocrinology

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