Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior.

Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior. Research Abstract Details 

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Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior. Abstract Text:

Hongkui Zeng,Brian A Schimpf,Alex D Rohde,Maria N Pavlova,Alexander Gragerov,John E Bergmann,Hongkui Zeng,Brian A Schimpf,Alex D Rohde,Maria N Pavlova,Alexander Gragerov,John E Bergmann,

TRH is a neuropeptide with a variety of hormonal and neurotransmitter/neuromodulator functions. In particular, TRH has pronounced acute antidepressant effects in both humans and animals and has been implicated in the mediation of the effects of other antidepressive therapies. Two G protein-coupled receptors, TRH receptor 1 (TRH-R1) and TRH-R2, have been identified. Here we report the generation and phenotypic characterization of mice deficient in TRH-R1. The TRH-R1 knockout mice have central hypothyroidism and mild hyperglycemia but exhibit normal growth and development and normal body weight and food intake. Behaviorally, the TRH-R1 knockout mice display increased anxiety and depression levels while behaving normally in a number of other aspects examined. These results provide the first direct evidence that the endogenous TRH system is involved in mood regulation, and this function is carried out through TRH-R1-mediated neural pathways.

Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior. Publishing Authors By Initials

H Zeng,BA Schimpf,AD Rohde,MN Pavlova,A Gragerov,JE Bergmann,H Zeng,BA Schimpf,AD Rohde,MN Pavlova,A Gragerov,JE Bergmann,

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Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular endocrinology (Baltimore, Md.)

VOLUME: 21

Page Numbers: 2795-804

Journal Abbreviation: Mol. Endocrinol.

ISSN: 0888-8809

DAY: 31

MONTH: 07

YEAR: 2007

Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior. Information

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LANGUAGE: eng

NlmUniqueID: 8801431

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Grant and Affiliation Information for Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior.

AFFILIATION: Omeros Corporation, 1420 Fifth Avenue, Suite 2600, Seattle, Washington 98101, USA. hongkuiz@alleninstitute.org

Country: United States

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MEDLINETA: Mol Endocrinol

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