Thyroid hormone status of newborns in relation to in utero exposure to PCBs and hydroxylated PCB metabolites.

Thyroid hormone status of newborns in relation to in utero exposure to PCBs and hydroxylated PCB metabolites. Research Abstract Details 

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Thyroid hormone status of newborns in relation to in utero exposure to PCBs and hydroxylated PCB metabolites. Abstract Text:

Takamitsu Otake,Jun Yoshinaga,Takeshi Enomoto,Muneaki Matsuda,Tadaaki Wakimoto,Miyuki Ikegami,Emiko Suzuki,Hiroshi Naruse,Tomoya Yamanaka,Noriko Shibuya,Takehiko Yasumizu,Nobumasa Kato,

The associations between in utero exposure to polychlorinated biphenyls (PCBs) or hydroxylated PCB metabolites (OH-PCBs), and free thyroxin (fT4) or thyroid-stimulating hormone (TSH) status in the newborn were investigated as a pilot study of a large-scale epidemiologic study on in utero PCB or OH-PCB exposure and thyroid function of the newborns. Umbilical cord tissue was used as the media for the biological monitoring of PCBs/OH-PCBs exposure in utero. For the measurement of fT4 and TSH, a heel-prick blood sample spotted on filter paper, which is called Guthrie card, is collected from each neonate at day 4-6 postpartum for this study when the mass screening sampling was performed. We showed that the concentration of total OH-PCBs and one of the OH-PCB congeners (OH-PCB 187) was related significantly to higher fT4 level of newborns. On the other hand, the concentration of total PCBs and PCB congeners (PCB 118, 138, 153, and 180) showed no relationship with fT4 and TSH level of the newborns. The results obtained in this pilot study indicated the possibility that in utero OH-PCBs exposure affects thyroid hormone status of newborns.

Thyroid hormone status of newborns in relation to in utero exposure to PCBs and hydroxylated PCB metabolites. Publishing Authors By Initials

T Otake,J Yoshinaga,T Enomoto,M Matsuda,T Wakimoto,M Ikegami,E Suzuki,H Naruse,T Yamanaka,N Shibuya,T Yasumizu,N Kato,

For similar embryonic structures: fetus: umbilical cord research abstracts see: embryonic structures: fetus: umbilical cord research

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Thyroid hormone status of newborns in relation to in utero exposure to PCBs and hydroxylated PCB metabolites. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Environmental research

VOLUME: 105

Page Numbers: 240-6

Journal Abbreviation: Environ. Res.

ISSN: 0013-9351

DAY: 8

MONTH: 05

YEAR: 2007

Thyroid hormone status of newborns in relation to in utero exposure to PCBs and hydroxylated PCB metabolites. Information

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LANGUAGE: eng

NlmUniqueID: 147621

Thyroid hormone status of newborns in relation to in utero exposure to PCBs and hydroxylated PCB metabolites. Keywords Mesh Terms:

KEYWORDS: Umbilical Cord

MESH TERMS: chemistry

Chemical & Substance for Abstract: Thyroid hormone status of newborns in relation to in utero exposure to PCBs and hydroxylated PCB metabolites. Information

Substance Name: Thyrotropin

Registry Number: 9002-71-5

Grant and Affiliation Information for Thyroid hormone status of newborns in relation to in utero exposure to PCBs and hydroxylated PCB metabolites.

AFFILIATION: Department of Environmental Studies, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8563, Japan.

Country: United States

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MEDLINETA: Environ Res

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