Thyroid hormone inhibits proliferation of fetal cardiac myocytes in vitro.

Thyroid hormone inhibits proliferation of fetal cardiac myocytes in vitro. Research Abstract Details 

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Thyroid hormone inhibits proliferation of fetal cardiac myocytes in vitro. Abstract Text:

N N Chattergoon,G D Giraud,K L Thornburg,

Thyroid hormone (T(3)) is a key regulator of fetal organ maturation. Premature elevations of thyroid hormone may lead to a 'mature' cardio-phenotype. Thyroid hormone will stimulate maturation of ovine fetal cardiomyocytes in culture by decreasing their proliferative capacity. Group 1 fetal cardiomyocytes (approximately 135 days gestation) were incubated with T3 (1.5, 3, 10, and 100 nM) and bromodeoxyuridine (BrdU; 10 microM) for 24 and 48 h. Group 2 cardiomyocytes were cultured with T3 alone for later protein analysis of cell cycle regulators. At all concentrations, T3 decreased BrdU uptake fourfold in serum media (P<0.001 versus serum, n=5). Following serum-free (SF) T3 treatment, BrdU uptake was inhibited when compared with serum (P<0.001 versus serum, n=5). p21 expression increased threefold (P<0.05 versus serum free, n=4) and cyclin D1 expression decreased twofold (P<0.05 versus serum, n=4) in T3-treated cardiomyocytes. (1) T3 inhibits fetal cardiomyocyte proliferation, while (2) p21 protein levels increase, and (3) cyclin D1 levels decrease. Thus, T3 may be a potent regulator of cardiomyocyte proliferation and maturation in the late gestation fetus.

Thyroid hormone inhibits proliferation of fetal cardiac myocytes in vitro. Publishing Authors By Initials

NN Chattergoon,GD Giraud,KL Thornburg,

For similar hormones, hormone substitutes, and hormone antagonists: hormones: thyroid hormones: thyronines: triiodothyronine research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: thyroid hormones: thyronines: triiodothyronine research

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Thyroid hormone inhibits proliferation of fetal cardiac myocytes in vitro. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of endocrinology

VOLUME: 192

Page Numbers: R1-8

Journal Abbreviation: J. Endocrinol.

ISSN: 0022-0795

DAY: 3

MONTH: Feb

YEAR: 2007

Thyroid hormone inhibits proliferation of fetal cardiac myocytes in vitro. Information

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LANGUAGE: eng

NlmUniqueID: 375363

Thyroid hormone inhibits proliferation of fetal cardiac myocytes in vitro. Keywords Mesh Terms:

KEYWORDS: Triiodothyronine

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Thyroid hormone inhibits proliferation of fetal cardiac myocytes in vitro. Information

Substance Name: Triiodothyronine

Registry Number: 6893-02-3

Grant and Affiliation Information for Thyroid hormone inhibits proliferation of fetal cardiac myocytes in vitro.

AFFILIATION: Heart Research Center, Oregon Health and Science University, Portland, Oregon 97239-3098, USA. chatterg@ohsu.edu

Country: England

AGENCY: United States NICHD

GRANT: P01HD34430

ACRONYM: HD

MEDLINETA: J Endocrinol

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