[Thyroid gland function after therapy of the laryngeal cancer: prospective examinations]

[Thyroid gland function after therapy of the laryngeal cancer: prospective examinations] Research Abstract Details 

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[Thyroid gland function after therapy of the laryngeal cancer: prospective examinations] Abstract Text:

D Sta?czyk,C Tarnowska,S Szostak,B Ko?odziej,P Maj,D Rogowska,A Jarema,

The paper presents the results of the study concerning thyroid gland function of the patients suffering from larynx cancer treated with: a) surgery only (n = 31), b) surgery with further radiotherapy with radical doses 5400-7000 cGy (n = 44), c) radiotherapy along with radical doses 6400-7000 cGy (n = 7). 82 patients (M-73, F-9) were examined. Average age was 58 (min. 30, max. 80). Thyroid gland function was evaluated by measurement of: a) hTSH, fT3, fT4, b) serum lipids concentration. The examinations mentioned above were performed before as well as after the treatment at: a) 1, b) 1-6, c) 6-12, d) 12-24, e) longer than 24 months after completion of treatment. The longest period of observation involved 8 years. Our results show that hypothyroidism (mostly subclinical) occurs seldom (6% of all the cases) in the early phase (up to 1 month) after surgical treatment. After radiotherapy only--no subclinical hypothyroidism was observed. The combined treatment seems to be the most frequent cause of subclinical hypothyroidism. Its frequency increases (up to 27%) with the length of time since the conclusion of treatment. We also tried to explain the pathogenesis of subclinical hypothyroidism on the basis of histopathologic examination of thyroid tissue (n = 13) derived from the patients after various ways of treatment. The studies were compared to the results of histological examinations of the thyroid sections obtained during autopsy (n = 20) from the control group (not suffered from thyroid diseases).

[Thyroid gland function after therapy of the laryngeal cancer: prospective examinations] Publishing Authors By Initials

D Sta?czyk,C Tarnowska,S Szostak,B Ko?odziej,P Maj,D Rogowska,A Jarema,

For similar endocrine system: endocrine glands: thyroid gland research abstracts see: endocrine system: endocrine glands: thyroid gland research

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[Thyroid gland function after therapy of the laryngeal cancer: prospective examinations] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Otolaryngologia polska. The Polish otolaryngology

VOLUME: 54 Suppl 31

Page Numbers: 45-8

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ISSN: 0030-6657

DAY: 28

MONTH: 12

YEAR: 2000

[Thyroid gland function after therapy of the laryngeal cancer: prospective examinations] Information

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LANGUAGE: pol

NlmUniqueID: 404453

[Thyroid gland function after therapy of the laryngeal cancer: prospective examinations] Keywords Mesh Terms:

KEYWORDS: Thyroid Gland

MESH TERMS: physiopathology

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Grant and Affiliation Information for [Thyroid gland function after therapy of the laryngeal cancer: prospective examinations]

AFFILIATION: Katedra i Klinika Otolaryngologii PAM.

Country: POLAND

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MEDLINETA: Otolaryngol Pol

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