Thymus and activation regulated chemokines in children with atopic dermatitis: Kyushu University Ishigaki Atopic Dermatitis Study (KIDS).

Thymus and activation regulated chemokines in children with atopic dermatitis: Kyushu University Ishigaki Atopic Dermatitis Study (KIDS). Research Abstract Details 

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Thymus and activation regulated chemokines in children with atopic dermatitis: Kyushu University Ishigaki Atopic Dermatitis Study (KIDS). Abstract Text:

Norihiro Furusyo,Hiroaki Takeoka,Kazuhiro Toyoda,Masayuki Murata,Shinji Maeda,Hachiro Ohnishi,Noriko Fukiwake,Hiroshi Uchi,Masutaka Furue,Jun Hayashi,Norihiro Furusyo,Hiroaki Takeoka,Kazuhiro Toyoda,Masayuki Murata,Shinji Maeda,Hachiro Ohnishi,Noriko Fukiwake,Hiroshi Uchi,Masutaka Furue,Jun Hayashi,

The purpose of this population-based study was to investigate the clinical significance of serum thymus and activation-regulated chemokine (TARC) in children with atopic dermatitis (AD). Between 2003 and 2004, 1359 Japanese children aged 5 years and under were prospectively followed. Serum levels of TARC by using an ELISA in each child were monitored throughout the study period. The first tested year, the mean serum level of TARC in children with sustained AD (mean; 691.7 pg/mL) was significantly higher than that of regressed AD children (569.9 pg/mL), newly developed AD children (380.1 pg/ mL), and healthy children (506.3 pg/mL). The changes of TARC levels in sustained AD children found no significance between 2003 (691.7 pg/mL) and 2004 (682.0 pg/mL). The mean levels of TARC of both regressed AD and healthy children significantly decreased from 2003 to 2004 (644.2 pg/mL to 448.7 pg/mL and 506.3 pg/mL to 442.1 pg/mL, respectively). The mean TARC level of newly developed AD children significantly increased from 2003 to 2004 (380.1 pg/mL to 491.8 pg/mL). We demonstrated strong associations between TARC levels and the natural course of childhood AD. Monitoring serum TARC levels of AD children may be useful for the biological evaluation of AD.

Thymus and activation regulated chemokines in children with atopic dermatitis: Kyushu University Ishigaki Atopic Dermatitis Study (KIDS). Publishing Authors By Initials

N Furusyo,H Takeoka,K Toyoda,M Murata,S Maeda,H Ohnishi,N Fukiwake,H Uchi,M Furue,J Hayashi,N Furusyo,H Takeoka,K Toyoda,M Murata,S Maeda,H Ohnishi,N Fukiwake,H Uchi,M Furue,J Hayashi,

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Thymus and activation regulated chemokines in children with atopic dermatitis: Kyushu University Ishigaki Atopic Dermatitis Study (KIDS). Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of dermatology : EJD

VOLUME: 17

Page Numbers: 397-404

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ISSN: 1167-1122

DAY: 2

MONTH: 08

YEAR: 2007

Thymus and activation regulated chemokines in children with atopic dermatitis: Kyushu University Ishigaki Atopic Dermatitis Study (KIDS). Information

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LANGUAGE: eng

NlmUniqueID: 9206420

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AFFILIATION: Department of General Medicine, Kyushu University Hospital, Higashi-Ku, Fukuoka, 812-8582 Japan. furusyo@genmedpr.med.kyushu-u.ac.jp

Country: France

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MEDLINETA: Eur J Dermatol

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