Thymosinalpha1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells.

Thymosinalpha1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells. Research Abstract Details 

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Thymosinalpha1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells. Abstract Text:

Min Li,Louis W Feurino,Fei Li,Hao Wang,Qihui Zhai,William E Fisher,Changyi Chen,Qizhi Yao,

In this study, we investigated the expression and function of thymosinalpha1 (Thyalpha1) in human pancreatic cancer. We found that human pancreatic cancer cell lines Panc-1, Panc03.27, ASPC-1, and PL45 cells significantly over-expressed the mRNA of Thyalpha1 as compared to the normal human pancreatic ductal epithelium (HPDE) cells.. Thyalpha1 mRNA and protein levels were also over-expressed in clinical pancreatic adenocarcinoma specimens. In addition, synthetic Thyalpha1 significantly promoted Panc-1 cell proliferation and increased phosphorylation of ERK1/2 and JNK. Furthermore, Thyalpha1 increased the secretion of multiple cytokines including IL-10, IL-13, and IL-17 in Panc-1 cells. Thus, Thyalpha1 may have a new role in pancreatic cancer pathogenesis.

Thymosinalpha1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells. Publishing Authors By Initials

M Li,LW Feurino,F Li,H Wang,Q Zhai,WE Fisher,C Chen,Q Yao,

For similar hormones, hormone substitutes, and hormone antagonists: hormones: thymus hormones: thymosin research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: thymus hormones: thymosin research

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Thymosinalpha1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer letters

VOLUME: 248

Page Numbers: 58-67

Journal Abbreviation: Cancer Lett.

ISSN: 0304-3835

DAY: 7

MONTH: 07

YEAR: 2006

Thymosinalpha1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells. Information

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LANGUAGE: eng

NlmUniqueID: 7600053

Thymosinalpha1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells. Keywords Mesh Terms:

KEYWORDS: Thymosin

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Thymosinalpha1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells. Information

Substance Name: Mitogen-Activated Protein Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Thymosinalpha1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells.

AFFILIATION: Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA. minili@bcm.tmc.edu

Country: Ireland

AGENCY: United States NCCAM

GRANT: R21 AT003094

ACRONYM: AT

MEDLINETA: Cancer Lett

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