Thymosin {alpha}1 activates the TLR9/MyD88/IRF7-dependent murine cytomegalovirus sensing for induction of anti-viral responses in vivo.

Thymosin {alpha}1 activates the TLR9/MyD88/IRF7-dependent murine cytomegalovirus sensing for induction of anti-viral responses in vivo. Research Abstract Details 

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Thymosin {alpha}1 activates the TLR9/MyD88/IRF7-dependent murine cytomegalovirus sensing for induction of anti-viral responses in vivo. Abstract Text:

Silvia Bozza,Roberta Gaziano,Pierluigi Bonifazi,Teresa Zelante,Lucia Pitzurra,Claudia Montagnoli,Silvia Moretti,Roberto Castronari,Paola Sinibaldi,Guido Rasi,Enrico Garaci,Francesco Bistoni,Luigina Romani,Silvia Bozza,Roberta Gaziano,Pierluigi Bonifazi,Teresa Zelante,Lucia Pitzurra,Claudia Montagnoli,Silvia Moretti,Roberto Castronari,Paola Sinibaldi,Guido Rasi,Enrico Garaci,Francesco Bistoni,Luigina Romani,Silvia Bozza,Roberta Gaziano,Pierluigi Bonifazi,Teresa Zelante,Lucia Pitzurra,Claudia Montagnoli,Silvia Moretti,Roberto Castronari,Paola Sinibaldi,Guido Rasi,Enrico Garaci,Francesco Bistoni,Luigina Romani,

Reactivation of latent human cytomegalovirus following allogeneic transplantation is a major cause of morbidity and mortality and predisposes to severe complications. Thymosin alpha1 (Talpha1), a naturally occurring thymic peptide, is approved for treatment of some viral infections and as an immune adjuvant. Talpha1 successfully primed dendritic cells (DCs) for anti-microbial T helper type 1 resistance through Toll-like receptor (TLR) 9 signaling. We sought to determine here whether Talpha1 could play a role in murine cytomegalovirus infection (MCMV). To this purpose, susceptible, resistant and TLR-deficient mice were infected with MCMV, treated with Talpha1 and assessed for protection in term of microbiological and immunological parameters. Talpha1 protected susceptible and resistant mice from MCMV infection. The anti-viral effect of Talpha1 occurred through the activation of plasmacytoid DCs via the TLR9/myeloid differentiation primary response gene 88-dependent viral recognition sensing, leading to the activation of IFN regulatory factor 7 and the promotion of the IFN-alpha/IFN-gamma-dependent effector pathway.

Thymosin {alpha}1 activates the TLR9/MyD88/IRF7-dependent murine cytomegalovirus sensing for induction of anti-viral responses in vivo. Publishing Authors By Initials

S Bozza,R Gaziano,P Bonifazi,T Zelante,L Pitzurra,C Montagnoli,S Moretti,R Castronari,P Sinibaldi,G Rasi,E Garaci,F Bistoni,L Romani,S Bozza,R Gaziano,P Bonifazi,T Zelante,L Pitzurra,C Montagnoli,S Moretti,R Castronari,P Sinibaldi,G Rasi,E Garaci,F Bistoni,L Romani,S Bozza,R Gaziano,P Bonifazi,T Zelante,L Pitzurra,C Montagnoli,S Moretti,R Castronari,P Sinibaldi,G Rasi,E Garaci,F Bistoni,L Romani,

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Thymosin {alpha}1 activates the TLR9/MyD88/IRF7-dependent murine cytomegalovirus sensing for induction of anti-viral responses in vivo. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International immunology

VOLUME: 19

Page Numbers: 1261-70

Journal Abbreviation: Int. Immunol.

ISSN: 0953-8178

DAY: 5

MONTH: 09

YEAR: 2007

Thymosin {alpha}1 activates the TLR9/MyD88/IRF7-dependent murine cytomegalovirus sensing for induction of anti-viral responses in vivo. Information

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LANGUAGE: eng

NlmUniqueID: 8916182

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AFFILIATION: Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Perugia, Italy.

Country: England

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MEDLINETA: Int Immunol

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