Thymosin alpha 1: from bench to bedside.

Thymosin alpha 1: from bench to bedside. Research Abstract Details 

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Thymosin alpha 1: from bench to bedside. Abstract Text:

Enrico Garaci,Cartesio Favalli,Francesca Pica,Paola Sinibaldi Vallebona,Anna Teresa Palamara,Claudia Matteucci,Pasquale Pierimarchi,Annalucia Serafino,Antonio Mastino,Francesco Bistoni,Luigina Romani,Guido Rasi,Enrico Garaci,Cartesio Favalli,Francesca Pica,Paola Sinibaldi Vallebona,Anna Teresa Palamara,Claudia Matteucci,Pasquale Pierimarchi,Annalucia Serafino,Antonio Mastino,Francesco Bistoni,Luigina Romani,Guido Rasi,

After the initial dramatic effects, observed in a Lewis lung carcinoma animal model, using a combination of thymosin alpha 1 (Talpha1) and interferon (IFN) after cyclophosphamide, a number of other preclinical models in mice (Friend erythroleukemia and B16 melanoma) and in rats (DHD/K12 colorectal cancer liver metastasis) have confirmed the efficacy of the combination therapy with Talpha1 and either IFN or IL-2 plus chemotherapy. These results provided the scientific foundation for the first clinical trials using Talpha1 in combination with BRMs and/or chemotherapy. Pivotal trials in advanced non-small cell lung cancer (NSCLC) and melanoma with Talpha1 and IFN-alpha low doses after cis-platinum or dacarbazine produced the first evidence of the high potentiality of this approach in the treatment of human cancer. The combination of Talpha1 and IFN-alpha was also used in patients affected by chronic B and C hepatitis including IFN-nonresponders and infected by precore mutants or genotype 1b. Further studies demonstrated additional biological activities clarifying the mechanism of action of Talpha1, partially explaining the synergism with IFN. It has been shown the capacity of activating infected dendritic cells through Toll-like receptor signaling, thus influencing the inflammation balance, and of increasing the expression of tumor, viral, and major histocompatibility complex (MHC) I antigens. Dose-response studies suggested the possibility of improving the efficacy of this molecule reducing the overall toxic. Based on these information two clinical trials are ongoing: a large phase II on advanced melanoma patients treated with Talpha1 at different doses after dacarbazine and a phase III one, on IFN-resistant hepatitis C virus (HCV) patients treated with a triple combination (IFN, ribavirin, and Talpha1).

Thymosin alpha 1: from bench to bedside. Publishing Authors By Initials

E Garaci,C Favalli,F Pica,P Sinibaldi Vallebona,A Teresa Palamara,C Matteucci,P Pierimarchi,A Serafino,A Mastino,F Bistoni,L Romani,G Rasi,E Garaci,C Favalli,F Pica,P Sinibaldi Vallebona,A Teresa Palamara,C Matteucci,P Pierimarchi,A Serafino,A Mastino,F Bistoni,L Romani,G Rasi,

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Thymosin alpha 1: from bench to bedside. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of the New York Academy of Sciences

VOLUME: 1112

Page Numbers: 225-34

Journal Abbreviation: Ann. N. Y. Acad. Sci.

ISSN: 0077-8923

DAY: 28

MONTH: 06

YEAR: 2007

Thymosin alpha 1: from bench to bedside. Information

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LANGUAGE: eng

NlmUniqueID: 7506858

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AFFILIATION: University of Rome Tor Vergata, Rome, Italy.

Country: United States

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MEDLINETA: Ann N Y Acad Sci

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