Thymic atrophy and regrowth in response to chemotherapy: CT evaluation.

Thymic atrophy and regrowth in response to chemotherapy: CT evaluation. Research Abstract Details 

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Thymic atrophy and regrowth in response to chemotherapy: CT evaluation. Abstract Text:

P L Choyke,R K Zeman,J E Gootenberg,J N Greenberg,F Hoffer,J A Frank,

Twenty-nine consecutive patients 2-35 years old underwent serial thoracic CT evaluations for metastatic disease. Thymic volumes were determined for each patient during cycles of chemotherapy and were compared with the patient's clinical status. This group included patients with Hodgkin's disease (13 patients), osteogenic sarcoma (five), testicular neoplasm (four), Wilms' tumor (three), rhabdomyosarcoma (two), malignant fibrous histiocytoma (one), and Ewing's sarcoma (one). Seven patients with mediastinal lymphoma had tumor involvement of the thymus and therefore were excluded. The 22 remaining patients showed cyclic thymic volume changes in response to chemotherapy or its discontinuance. During the first course of chemotherapy the thymic volume decreased by an average of 43% in 20 of 22 patients. Between the first and second course, regrowth was observed in all 20 of these patients. Among the six patients who received a second course of therapy, an average volume decrease of 36% was observed during the second course with regrowth again occurring during recovery from chemotherapy. Thymic rebound (regrowth 50% greater than baseline volume) occurred in five patients, three of whom were in clinical remission. The thymus appears to atrophy during the administration of chemotherapy and regrow during the recovery phase of chemotherapy in 90% of the patients studied. Thymic hyperplasia or rebound is a relatively common phenomenon occurring in 25% of patients. The size of the thymus appears to be extremely sensitive to chemotherapy.

Thymic atrophy and regrowth in response to chemotherapy: CT evaluation. Publishing Authors By Initials

PL Choyke,RK Zeman,JE Gootenberg,JN Greenberg,F Hoffer,JA Frank,

For similar tomography, x-ray computed research abstracts see: tomography, x-ray computed research

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Thymic atrophy and regrowth in response to chemotherapy: CT evaluation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: AJR. American journal of roentgenology

VOLUME: 149

Page Numbers: 269-72

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ISSN: 0361-803X

DAY: 15

MONTH: Aug

YEAR: 1987

Thymic atrophy and regrowth in response to chemotherapy: CT evaluation. Information

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LANGUAGE: eng

NlmUniqueID: 7708173

Thymic atrophy and regrowth in response to chemotherapy: CT evaluation. Keywords Mesh Terms:

KEYWORDS: Tomography, X-Ray Computed

MESH TERMS: radiography

Chemical & Substance for Abstract: Thymic atrophy and regrowth in response to chemotherapy: CT evaluation. Information

Substance Name: Antineoplastic Agents

Registry Number: 0

Grant and Affiliation Information for Thymic atrophy and regrowth in response to chemotherapy: CT evaluation.

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Country: UNITED STATES

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MEDLINETA: AJR Am J Roentgenol

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