Thymectomy does not abrogate long-term acceptance of MHC class I-disparate lung allografts in miniature Swine.

Thymectomy does not abrogate long-term acceptance of MHC class I-disparate lung allografts in miniature Swine. Research Abstract Details 

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Thymectomy does not abrogate long-term acceptance of MHC class I-disparate lung allografts in miniature Swine. Abstract Text:

H Sahara,M J Weiss,C Y Ng,S L Houser,A C Pujara,J K Sayre,J C Wain,D H Sachs,J C Madsen,J S Allan,

We have previously reported that tolerance to class I disparate lung allografts in miniature swine could be induced using an intensive 12-day course of tacrolimus and that pretransplant sensitization with immunogenic MHC class I allopeptides failed to block the induction of tolerance. We also have previously reported the importance of the presence of the thymus in the induction of tolerance to isolated heart, kidney, and combined heart-kidney transplants. In this study, we examined the impact of thymectomy on tolerance induction in lung transplantation. METHODS: Orthotopic left lung transplantation was performed using MHC class I-disparate donors. The recipients received a 12-day course of high-dose tacrolimus (n = 6). Total thymectomies were performed in three of the swine 21 days prior to transplantation. Lung grafts were monitored by chest radiography and serial open lung biopsy. RESULTS: All euthymic recipients maintained their grafts for over 1 year. None of the thymectomized recipients has experienced graft loss in the 6 to 10 months following transplantation. Although isolated lesions of obliterative bronchiolitis were occasionally seen in one thymectomized animal on biopsy, donor-specific unresponsiveness has been observed on assays of cell-mediated lymphocytotoxicity in all recipients. Moreover, co-culture assays have shown that recipient lymphocytes can strongly inhibit the normally robust response of naïve recipient-matched lymphocytes to donor antigen. This inhibition was not seen when using stimulators primed with third-party antigens against appropriate targets. CONCLUSIONS: These data suggest that thymus-independent peripheral regulatory mechanisms may be sufficient to induce and maintain long-term acceptance of the lung allografts.

Thymectomy does not abrogate long-term acceptance of MHC class I-disparate lung allografts in miniature Swine. Publishing Authors By Initials

H Sahara,MJ Weiss,CY Ng,SL Houser,AC Pujara,JK Sayre,JC Wain,DH Sachs,JC Madsen,JS Allan,

For similar surgical procedures, operative: transplantation: transplantation, homologous research abstracts see: surgical procedures, operative: transplantation: transplantation, homologous research

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Thymectomy does not abrogate long-term acceptance of MHC class I-disparate lung allografts in miniature Swine. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Transplantation proceedings

VOLUME: 38

Page Numbers: 3253-5

Journal Abbreviation: Transplant. Proc.

ISSN: 0041-1345

DAY: 3

MONTH: Dec

YEAR: 2006

Thymectomy does not abrogate long-term acceptance of MHC class I-disparate lung allografts in miniature Swine. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 243532

Thymectomy does not abrogate long-term acceptance of MHC class I-disparate lung allografts in miniature Swine. Keywords Mesh Terms:

KEYWORDS: Transplantation, Homologous

MESH TERMS: immunology

Chemical & Substance for Abstract: Thymectomy does not abrogate long-term acceptance of MHC class I-disparate lung allografts in miniature Swine. Information

Substance Name: Tacrolimus

Registry Number: 109581-93-3

Grant and Affiliation Information for Thymectomy does not abrogate long-term acceptance of MHC class I-disparate lung allografts in miniature Swine.

AFFILIATION: Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: 1R01-HL67110-01-A1

ACRONYM: HL

MEDLINETA: Transplant Proc

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