Thrombin regulates the function of human blood dendritic cells.

Thrombin regulates the function of human blood dendritic cells. Research Abstract Details 

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Thrombin regulates the function of human blood dendritic cells. Abstract Text:

Manabu Yanagita,Ryohei Kobayashi,Yoichiro Kashiwagi,Yoshio Shimabukuro,Shinya Murakami,Manabu Yanagita,Ryohei Kobayashi,Yoichiro Kashiwagi,Yoshio Shimabukuro,Shinya Murakami,

Thrombin is the key enzyme in the coagulation cascade and activates endothelial cells, neutrophils and monocytes via protease-activated receptors (PARs). At the inflammatory site, immune cells have an opportunity to encounter thrombin. However little is known about the effect of thrombin for dendritic cells (DC), which are efficient antigen-presenting cells and play important roles in initiating and regulating immune responses. The present study revealed that thrombin has the ability to stimulate blood DC. Plasmacytoid DC (PDC) and myeloid DC (MDC) isolated from PBMC expressed PAR-1 and released MCP-1, IL-10, and IL-12 after thrombin stimulation. Unlike blood DC, monocyte-derived DC (MoDC), differentiated in vitro did not express PAR-1 and were unresponsive to thrombin. Effects of thrombin on blood DC were significantly diminished by the addition of anti-PAR-1 Ab or hirudin, serine protease inhibitor. Moreover, thrombin induced HLA-DR and CD86 expression on DC and the thrombin-treated DC induced allogenic T cell proliferation. These findings indicate that thrombin plays a role in the regulation of blood DC functions.

Thrombin regulates the function of human blood dendritic cells. Publishing Authors By Initials

M Yanagita,R Kobayashi,Y Kashiwagi,Y Shimabukuro,S Murakami,M Yanagita,R Kobayashi,Y Kashiwagi,Y Shimabukuro,S Murakami,

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Thrombin regulates the function of human blood dendritic cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 364

Page Numbers: 318-24

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 1090-2104

DAY: 11

MONTH: 10

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Thrombin regulates the function of human blood dendritic cells.

AFFILIATION: Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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