Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse.

Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse. Research Abstract Details 

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Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse. Abstract Text:

Kathryn E Nichol,Anna I Parachikova,Carl W Cotman,Kathryn E Nichol,Anna I Parachikova,Carl W Cotman,Kathryn E Nichol,Anna I Parachikova,Carl W Cotman,

If begun early in life, exercise effectively reduces the development of cognitive deficits in transgenic mouse models of Alzheimer's disease (AD). However, the effectiveness of exercise, once the cognitive impairments are established, is not as clear. In terms of translating research in animal models to treatments involving exercise in Alzheimer's disease patients, it is critical to evaluate exercise intervention at time points that address not only prevention, but also treatment of cognitive decline. We provided exercise wheels to Tg2576 (TG) (n=12) and C57BL6 (WT) (n=17) mice at 16-18 months of age for three weeks. At this age animals have significant cognitive impairment and neuropathology consistent with AD. Age matched sedentary TG (n=13) and WT (n=12) mice were also included, as well as groups provided access to an immobile wheel (TG n=9, WT n=12). After three weeks, animals were evaluated in a radial arm water maze. Significant impairments were observed in the sedentary TG mice compared to WT in reference/long-term and working/short-term memory, as well as in probe trials. Exercised TG mice demonstrated improvements in memory, which made them indistinguishable from WT mice on all tasks. In addition, animals provided with an immobile wheel exhibited improvement in some, but not all cognitive measures. Our findings demonstrate that exercise can improve cognitive performance in a mouse model of AD even if applied after the development of pathology.

Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse. Publishing Authors By Initials

KE Nichol,AI Parachikova,CW Cotman,KE Nichol,AI Parachikova,CW Cotman,KE Nichol,AI Parachikova,CW Cotman,

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Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Behavioural brain research

VOLUME: 184

Page Numbers: 124-32

Journal Abbreviation: Behav. Brain Res.

ISSN: 0166-4328

DAY: 10

MONTH: 07

YEAR: 2007

Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse. Information

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LANGUAGE: eng

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AFFILIATION: Institute for Brain Aging & Dementia, University of California at Irvine, Irvine, CA 92697-4540, USA. knichol@uci.edu

Country: Netherlands

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MEDLINETA: Behav Brain Res

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