Three new high-prevalence antigens in the Cromer blood group system.

Three new high-prevalence antigens in the Cromer blood group system. Research Abstract Details 

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Three new high-prevalence antigens in the Cromer blood group system. Abstract Text:

Kim Hue-Roye,Christine Lomas-Francis,Larisa Belaygorod,Douglas M Lublin,Janet Barnes,Amy Chung,Karen Fung-Kee-Fung,Jeff Kinney,Ronit Goldman-Lavi,Vered Yahalom,Joyce Poole,Zdravko Ivankovic,Denden Alcantara,Marija Bekavac,Branka Golubic Cepulic,Randall W Velliquette,Richard Mason,Marion E Reid,

BACKGROUND: The Cromer blood group system consists of nine high-prevalence and three low-prevalence antigens carried on decay-accelerating factor (DAF). This report describes three new Cromer high-prevalence antigens, named ZENA, CROV, and CRAM. STUDY DESIGN AND METHODS: Sequence analyses were performed on DNA from three probands whose serum samples each contained an alloantibody to a high-prevalence antigen in the Cromer blood group system. Polymerase chain reaction-restriction fragment length polymorphism analysis to detect the mutation encoding the CROV- phenotype was performed on 100 Croatian donors. To map the respective epitopes, DAF deletion mutants were tested by immunoblotting with eluates containing the antibodies. RESULTS: In each proband, sequence analysis revealed a single-nucleotide substitution in DAF: ZENA, 726T>G mutation, predicted change His242Gln; CROV, 466G>A mutation, predicted change Glu156Lys; and CRAM, 740A>G mutation, predicted change Gln247Arg. By analysis of DAF deletion mutants, the CROV antigenic determinant mapped to the complement control protein (CCP) domain 2, which is encoded by exon 3, whereas ZENA and CRAM mapped to CCP4, which is encoded by exon 6. CONCLUSION: This study describes three novel high-prevalence antigens in the Cromer blood group system each characterized by a predicted single-amino-acid substitution. The antigens have been assigned the following International Society of Blood Transfusion (ISBT) numbers: ZENA is CROM13, CROV is CROM14, and CRAM is CROM15.

Three new high-prevalence antigens in the Cromer blood group system. Publishing Authors By Initials

K Hue-Roye,C Lomas-Francis,L Belaygorod,DM Lublin,J Barnes,A Chung,K Fung-Kee-Fung,J Kinney,R Goldman-Lavi,V Yahalom,J Poole,Z Ivankovic,D Alcantara,M Bekavac,BG Cepulic,RW Velliquette,R Mason,ME Reid,

For similar genetic processes: mutagenesis: sequence deletion research abstracts see: genetic processes: mutagenesis: sequence deletion research

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Three new high-prevalence antigens in the Cromer blood group system. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Transfusion

VOLUME: 47

Page Numbers: 1621-9

Journal Abbreviation: Transfusion

ISSN: 0041-1132

DAY: 3

MONTH: Sep

YEAR: 2007

Three new high-prevalence antigens in the Cromer blood group system. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 417360

Three new high-prevalence antigens in the Cromer blood group system. Keywords Mesh Terms:

KEYWORDS: Sequence Deletion

MESH TERMS: genetics

Chemical & Substance for Abstract: Three new high-prevalence antigens in the Cromer blood group system. Information

Substance Name: DNA, Complementary

Registry Number: 0

Grant and Affiliation Information for Three new high-prevalence antigens in the Cromer blood group system.

AFFILIATION: Laboratory of Immunochemistry and the Laboratory of Immunohematology, New York Blood Center, New York, New York, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL54459

ACRONYM: HL

MEDLINETA: Transfusion

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