Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events.

Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events. Abstract Text:

S Pattanakitsakul,K Nakayama,M Takahashi,M Nonaka,

Mice bearing the H-2w7 haplotype have five C4-related genes and constitutively express the Slp antigen. To understand the structure and evolution of the five C4-related genes of the C3H.W7 mouse, we have determined nucleotide sequences of the 5' end region of these genes. A C4/Slp hybrid nature was confirmed for three of five C4-related genes as predicted previously by restriction enzyme analysis. The nucleotide sequences of the 5' flanking regions of these three hybrid genes showed close similarity to that of the C4 gene, while the 3' side of the ninth exon of the three hybrid genes showed close similarity to that of the Slp gene. In contrast, the regions between the first exon and the middle of the ninth exon of the three hybrid genes showed a mosaic structure of C4-like and Slp-like sequences. Moreover, the boundaries of the C4-like and Slp-like sequences were quite different among the three hybrid genes. The pattern of nucleotide sequence diversity in this region among the five C4-related sequences could be mainly explained not by point mutations but by gene conversions or unequal crossovers. These results suggest that multiple genetic recombinational events between two homologous sequences played an important role in the generation and diversification of the extra copies of the C4/Slp gene in the H-2w7 mouse.

Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events. Publishing Authors By Initials

S Pattanakitsakul,K Nakayama,M Takahashi,M Nonaka,

For similar genetic processes: recombination, genetic research abstracts see: genetic processes: recombination, genetic research

PUBMED ID PMID:

MEDLINE DATE:

Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Immunogenetics

VOLUME: 32

Page Numbers: 431-9

Journal Abbreviation: Immunogenetics

ISSN: 0093-7711

DAY: 11

MONTH: 12

YEAR: 1990

Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 420404

Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events. Keywords Mesh Terms:

KEYWORDS: Recombination, Genetic

MESH TERMS: genetics

Chemical & Substance for Abstract: Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events. Information

Substance Name: H-2 Antigens

Registry Number: 0

Grant and Affiliation Information for Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events.

AFFILIATION: Department of Immunobiology, Kanazawa University, Japan.

Country: UNITED STATES

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Immunogenetics

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER: D90171

Number Hits: 0

Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events Related Publications

• A study of monocytic and dendritic cell markers in benign cutaneous fibrous histiocytoma (dermatofibroma).
• Alexander disease: clinical, electrodiagnostic and radiographic studies.
• An experimental model of brain metastasis of lung carcinoma.
• Analysis of the reactivity of microsomal cytochrome P-450 toward drugs and exogenous ligands.
• Apoptosis is suspended in muscle of mitochondrial encephalomyopathies.
• Co-existence of nemaline and cytoplasmic bodies in muscle of an infant with nemaline myopathy.
• Correlations between incisor and condylar movements during lateral excursion in children with primary dentition.
• Crystallization and preliminary x-ray crystallographic analysis of galectin LEC-1 from Caenorhabditis elegans.
• Early onset of X-linked Emery-Dreifuss muscular dystrophy in a boy with emerin gene deletion.
• Evidence for the common evolutionary origin of the C4/Slp loci in the two wild mouse derived H-2 haplotypes, w7 and w19.
• In vitro inhibition of Helicobacter pylori by several dietary plant agents.
• Muscle involvement in a case of oculocutaneous albinism.
• Neurotological findings in Bell's palsy and Hunt's syndrome.
• Off-Bragg analysis of the diffraction efficiency of transmission photorefractive holograms.
• Off-bragg analysis of the diffraction efficiency of reflection photorefractive holograms.
• Specific binding of a hepatoma nuclear factor to the NF.kappa B/H2TF1 recognition motif found in the C4 promoter, but not in the Slp promoter.
• The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquine myopathy.
• Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events.
• Transverse velocity dependence of the proton-antiproton ratio as a signature of the QCD critical point.
• [Case study of 2 students in pediatric nursing practice]
• [High-dose intravenous immunoglobulin treatment]
• [Malignant lymphoma in a patient with chronic empyema]
• [Trial of a contact lens with mesh coating and its effect on visual function. 1. Its anti-glare effects.]