Three-dimensional models of individual cardiac histoanatomy: tools and challenges.

Three-dimensional models of individual cardiac histoanatomy: tools and challenges. Research Abstract Details 

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Three-dimensional models of individual cardiac histoanatomy: tools and challenges. Abstract Text:

Rebecca A B Burton,Gernot Plank, Schneider,Vicente Grau,Helmut Ahammer,Stephen L Keeling,Jack Lee,Nicolas P Smith,David Gavaghan,Natalia Trayanova,Peter Kohl,

There is a need for, and utility in, the acquisition of data sets of cardiac histoanatomy, with the vision of reconstructing individual hearts on the basis of noninvasive imaging, such as MRI, enriched by reference to detailed atlases of serial histology obtained from representative samples. These data sets would be useful not only as a repository of knowledge regarding the specifics of cardiac histoanatomy, but could form the basis for generation of individualized high-resolution cardiac structure-function models. The current article presents a step in this general direction: it illustrates how whole-heart noninvasive imaging can be combined with whole-heart histology in an approach to achieve automated construction of histoanatomically detailed models of cardiac 3D structure and function at hitherto unprecedented resolution and accuracy (based on 26.4 x 26.4 x 24.4 microm MRI voxel size, and enriched by histological detail). It provides an overview of the tools used in this quest and outlines challenges posed by the approach in the light of applications that may benefit from the availability of such data and tools.

Three-dimensional models of individual cardiac histoanatomy: tools and challenges. Publishing Authors By Initials

RA Burton,G Plank,JE Schneider,V Grau,H Ahammer,SL Keeling,J Lee,NP Smith,D Gavaghan,N Trayanova,P Kohl,

For similar animals: chordata: vertebrates: mammals: lagomorpha: rabbits research abstracts see: animals: chordata: vertebrates: mammals: lagomorpha: rabbits research

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Three-dimensional models of individual cardiac histoanatomy: tools and challenges. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Annals of the New York Academy of Sciences

VOLUME: 1080

Page Numbers: 301-19

Journal Abbreviation: Ann. N. Y. Acad. Sci.

ISSN: 0077-8923

DAY: 3

MONTH: Oct

YEAR: 2006

Three-dimensional models of individual cardiac histoanatomy: tools and challenges. Information

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LANGUAGE: eng

NlmUniqueID: 7506858

Three-dimensional models of individual cardiac histoanatomy: tools and challenges. Keywords Mesh Terms:

KEYWORDS: Rabbits

MESH TERMS: anatomy & histology

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Grant and Affiliation Information for Three-dimensional models of individual cardiac histoanatomy: tools and challenges.

AFFILIATION: Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK.

Country: United States

AGENCY: United States NHLBI

GRANT: HL 63195

ACRONYM: HL

MEDLINETA: Ann N Y Acad Sci

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