Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0T.

Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0T. Research Abstract Details 

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Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0T. Abstract Text:

Charles A McKenzie,Ashley Williams,Pottumarthi V Prasad,Deborah Burstein,

PURPOSE: To implement and validate a three-dimensional (3D) T1 measurement technique that is suitable for delayed gadolinium (Gd)-enhanced MRI of cartilage (dGEMRIC) and can be easily implemented with clinically available pulse sequences at 1.5T and 3.0T. MATERIALS AND METHODS: A 3D inversion-recovery prepared spoiled gradient-echo (IR-SPGR) imaging pulse sequence with variable TR was used to implement a 3D T1 measurement protocol. The 3D T1 measurements were validated against a gold-standard single-slice 2D IR T1 measurement protocol in both phantoms and in vivo, in both asymptomatic volunteers and volunteers with osteoarthritis (OA). RESULTS: T1 measurements in phantoms showed a statistically significant correlation between the 2D and 3D measurements at 1.5T (R2=0.993, P<0.001) and 3.0T (R2=0.996, P<0.001). In vivo application demonstrated the feasibility of using this 3D IR-SPGR sequence to evaluate the molecular status of articular cartilage throughout the knee joint with 0.63x0.63x3.0 mm spatial resolution within a 20-minute acquisition, even with the measurement parameters set for the higher T1(Gd) of cartilage at 3T (range=400-900 msec mean T1 within a region of interest (ROI) in cartilage, compared to 200-600 msec mean T1 at 1.5T). CONCLUSION: This 3D T1 measurement protocol may prove useful for the evaluation and follow-up of cartilage dGEMRIC indices in clinical studies of OA.

Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0T. Publishing Authors By Initials

CA McKenzie,A Williams,PV Prasad,D Burstein,

For similar equipment and supplies: phantoms, imaging research abstracts see: equipment and supplies: phantoms, imaging research

PUBMED ID PMID:

MEDLINE DATE:

Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0T. Journal Published:

PUBLICATION TYPE: Validation Studies

Journal: Journal of magnetic resonance imaging : JMRI

VOLUME: 24

Page Numbers: 928-33

Journal Abbreviation:

ISSN: 1053-1807

DAY: 3

MONTH: Oct

YEAR: 2006

Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0T. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9105850

Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0T. Keywords Mesh Terms:

KEYWORDS: Phantoms, Imaging

MESH TERMS: pathology

Chemical & Substance for Abstract: Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0T. Information

Substance Name: Gadolinium DTPA

Registry Number: 80529-93-7

Grant and Affiliation Information for Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0T.

AFFILIATION: Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. charles_mckenzie@caregroup.harvard.edu

Country: United States

AGENCY: United States NIAMS

GRANT: AR042773

ACRONYM: AR

MEDLINETA: J Magn Reson Imaging

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