Three-dimensional degradable porous polymer-ceramic matrices for use in bone repair.

Three-dimensional degradable porous polymer-ceramic matrices for use in bone repair. Research Abstract Details 

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Three-dimensional degradable porous polymer-ceramic matrices for use in bone repair. Abstract Text:

J E Devin,M A Attawia,C T Laurencin,

A degradable polymer-ceramic matrix for use as a bone graft material is described. The fabrication method used produces 3-dimensional macroporous matrices which are structurally similar to cancellous bone in their porosity, mechanically similar to cancellous bone in compressive elastic modulus and chemically comparable to the mineral matrix of bone in that they contain hydroxyapatite (HA). A 50:50 copolymer of poly(lactide/glycolide) (PLAGA) reinforced by a particulate calcium phosphate ceramic, HA, was used to create a matrix composed of polymeric microspheres. The channels between these spheres were pores approximately 100 microns in diameter. Four polymer/ceramic ratios were used in matrix fabrication: 1:0, 1:1, 2.5:1, and 5:1. The mechanical behavior of the material was found to vary with ceramic content. Increased levels of HA resulted in increased compressive elastic moduli. Prior to polymer degradation, moduli ranged from a high of 1459 MPa (50% HA) to a low of 293 MPa (0% HA). Degradation studies over a 6-week period showed that 0 and 16.7% HA-containing matrices lost up to 50% of their original weight, while the 28.6 and 50% IIA-containing matrices lost up to 20% of their original weight. Increased HA matrix content translated into decreased rates of matrix degradation. Environmental scanning electron microscopy (ESEM) confirmed that the polymer matrix contained pores that were interconnected during degradation. Viewed via ESEM, 10% HA containing matrices completely degraded by 6 weeks, while 50% HA matrices remained relatively stable. These studies indicate that the porous 3-dimensional polymer/ceramic matrix may potentially be useful as a synthetic material for bone repair.

Three-dimensional degradable porous polymer-ceramic matrices for use in bone repair. Publishing Authors By Initials

JE Devin,MA Attawia,CT Laurencin,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Three-dimensional degradable porous polymer-ceramic matrices for use in bone repair. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 7

Page Numbers: 661-9

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ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 1996

Three-dimensional degradable porous polymer-ceramic matrices for use in bone repair. Information

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LANGUAGE: eng

NlmUniqueID: 9007393

Three-dimensional degradable porous polymer-ceramic matrices for use in bone repair. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: chemistry

Chemical & Substance for Abstract: Three-dimensional degradable porous polymer-ceramic matrices for use in bone repair. Information

Substance Name: Lactic Acid

Registry Number: 50-21-5

Grant and Affiliation Information for Three-dimensional degradable porous polymer-ceramic matrices for use in bone repair.

AFFILIATION: Helen I. Moorehead-Laurencin Biomaterials Research Laboratory, Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, USA.

Country: NETHERLANDS

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MEDLINETA: J Biomater Sci Polym Ed

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