Three-dimensional bone-implant integration profiling using micro-computed tomography.

Three-dimensional bone-implant integration profiling using micro-computed tomography. Research Abstract Details 

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Three-dimensional bone-implant integration profiling using micro-computed tomography. Abstract Text:

Frank Butz,Takahiro Ogawa,Ting-Ling Chang,Ichiro Nishimura,

PURPOSE: The capability of micro-computed tomography (microCT) for quantitative analysis of peri-implant bone has not been previously addressed. This study aimed to establish and validate a method to use this technique for 3-dimensional bone-implant integration profiling. MATERIALS AND METHODS: Unthreaded cylindric implants with a dual acid-etched surface were placed into the right femurs of 7 Sprague-Dawley rats. Two weeks postimplantation, the femurs were harvested and measured with a desktop micro-tomographic scanner with an isotropic resolution of 8 microm. To validate the microCT outcome, ground histologic sections and corresponding CT slices were compared with respect to bone morphometry. RESULTS: Bone-implant integration profiles assessed by microCT revealed that the percentage of cancellous bone gradually increased with proximity to the implant surface, while the percentage of cortical bone was not affected by proximity to the implant. Using the optimized segmentation threshold, the bone configuration in the microCT images corresponded to that observed in the histologic sections. The correlation between microCT and histology was significant for cortical (r = 0.65; P < .05) and cancellous bone (r = 0.92; P < .05) at distances of 24 to 240 microm from the implant surface, but no significant correlation was found for the area from 0 to 24 microm from the surface. DISCUSSION AND CONCLUSION: The results support the usefulness of microCT assessment as a rapid, nondestructive method for 3-dimensional bone ratio measurements around implants, which may provide new perspectives for osseointegration research. Further study is necessary, however, to address the inherent metallic halation artifact, which potentially confounds peri-implant bone assessment.

Three-dimensional bone-implant integration profiling using micro-computed tomography. Publishing Authors By Initials

F Butz,T Ogawa,TL Chang,I Nishimura,

For similar tomography, x-ray computed research abstracts see: tomography, x-ray computed research

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MEDLINE DATE:

Three-dimensional bone-implant integration profiling using micro-computed tomography. Journal Published:

PUBLICATION TYPE: Validation Studies

Journal: The International journal of oral & maxillofacial

VOLUME: 21

Page Numbers: 687-95

Journal Abbreviation:

ISSN: 0882-2786

DAY: 3

MONTH: 12

YEAR: 2007

Three-dimensional bone-implant integration profiling using micro-computed tomography. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8611905

Three-dimensional bone-implant integration profiling using micro-computed tomography. Keywords Mesh Terms:

KEYWORDS: Tomography, X-Ray Computed

MESH TERMS: methods

Chemical & Substance for Abstract: Three-dimensional bone-implant integration profiling using micro-computed tomography. Information

Substance Name: Dental Implants

Registry Number: 0

Grant and Affiliation Information for Three-dimensional bone-implant integration profiling using micro-computed tomography.

AFFILIATION: The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, University of California at Los Angeles School of Dentistry, 90095-1668, USA.

Country: United States

AGENCY: United States NCRR

GRANT: C06 RR014529

ACRONYM: RR

MEDLINETA: Int J Oral Maxillofac Implants

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