Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis.

Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis. Research Abstract Details 

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Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis. Abstract Text:

Stuart Jon Spechler,Robert M Genta,Rhonda F Souza,

Recent data suggest that the interaction between gastroesophageal reflux disease (GERD) and eosinophilic esophagitis can be complex, and that the notion of establishing a clear distinction between the two disorders may be too simplistic. There are at least four situations in which GERD might be associated with esophageal eosinophils: (a) GERD causes esophageal injury that results in a mild eosinophilic infiltration, (b) GERD and eosinophilic esophagitis coexist but are unrelated, (c) eosinophilic esophagitis contributes to or causes GERD, or (d) GERD contributes to or causes eosinophilic esophagitis. The high frequency of GERD described in adult patients with eosinophilic esophagitis suggests that there may be more than a chance association between the two disorders. This report discusses potential mechanisms for the complex interaction between GERD and eosinophilic esophagitis. We hope that this information will serve as a conceptual basis for future studies on the relationship between the two disorders. Whereas there are a number of plausible mechanisms whereby GERD might contribute to the accumulation of eosinophils in the esophageal epithelium, it seems prudent to recommend a clinical trial of proton pump inhibitor (PPI) therapy even when the diagnosis of eosinophilic esophagitis seems clear-cut. Furthermore, we suggest that a favorable response to PPI therapy does not preclude a diagnosis of eosinophilic esophagitis.

Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis. Publishing Authors By Initials

SJ Spechler,RM Genta,RF Souza,

For similar proteins: carrier proteins: membrane transport proteins: ion pumps: cation transport proteins: proton pumps research abstracts see: proteins: carrier proteins: membrane transport proteins: ion pumps: cation transport proteins: proton pumps research

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Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis. Journal Published:

PUBLICATION TYPE: Review

Journal: The American journal of gastroenterology

VOLUME: 102

Page Numbers: 1301-6

Journal Abbreviation: Am. J. Gastroenterol.

ISSN: 0002-9270

DAY: 3

MONTH: Jun

YEAR: 2007

Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis. Information

Number of References: 54

LANGUAGE: eng

NlmUniqueID: 421030

Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis. Keywords Mesh Terms:

KEYWORDS: Proton Pumps

MESH TERMS: antagonists & inhibitors

Chemical & Substance for Abstract: Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis. Information

Substance Name: Proton Pumps

Registry Number: 0

Grant and Affiliation Information for Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis.

AFFILIATION: Department of Medicine, Dallas Department of Veterans Affairs Medical Center, and The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75216, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK63621

ACRONYM: DK

MEDLINETA: Am J Gastroenterol

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