Thiosulfinates from Allium tuberosum L. induce apoptosis via caspase-dependent and -independent pathways in PC-3 human prostate cancer cells.

Thiosulfinates from Allium tuberosum L. induce apoptosis via caspase-dependent and -independent pathways in PC-3 human prostate cancer cells. Research Abstract Details 

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Thiosulfinates from Allium tuberosum L. induce apoptosis via caspase-dependent and -independent pathways in PC-3 human prostate cancer cells. Abstract Text:

So-Yeon Kim,Kyoung-Wuk Park,Jae-Yong Kim,Il-Yun Jeong,Myung-Woo Byun,Jung-Eun Park,Sung-Tae Yee,Kee-Hong Kim,Johng S Rhim,Koji Yamada,Kwon-Il Seo,So-Yeon Kim,Kyoung-Wuk Park,Jae-Yong Kim,Il-Yun Jeong,Myung-Woo Byun,Jung-Eun Park,Sung-Tae Yee,Kee-Hong Kim,Johng S Rhim,Koji Yamada,Kwon-Il Seo,

This study was aimed to evaluate the apoptotic effects of thiosulfinates purified from Allium tuberosum L. on PC-3 human prostate cancer cells, and to elucidate detailed apoptosis mechanisms. Thiosulfinates significantly decrease viable cell numbers in dose- and time-dependent manners by apoptotic cell death via DNA fragmentation, chromatin condensation, and an increased sub-G1 phase. Apoptosis induced by thiosulfinates is associated with the activation of initiator caspase-8 and -9, and the effector caspase-3. In this study, thiosulfinates stimulated Bid cleavage, indicating that the apoptotic action of caspase-8-mediated Bid cleavage leads to the activation of caspase-9. Thiosulfinates decreased the expression of the anti-apoptotic protein Bcl-2 and increased the expression of the pro-apoptotic protein Bax. Thiosulfinates also increased the expression of AIF, a caspase-independent mitochondrial apoptosis factor, in PC-3 cells. These results indicate that thiosulfinates from A. tuberosum L. inhibit cell proliferation and induce apoptosis in PC-3 cells, which may be mediated via both caspase-dependent and -independent pathways.

Thiosulfinates from Allium tuberosum L. induce apoptosis via caspase-dependent and -independent pathways in PC-3 human prostate cancer cells. Publishing Authors By Initials

SY Kim,KW Park,JY Kim,IY Jeong,MW Byun,JE Park,ST Yee,KH Kim,JS Rhim,K Yamada,KI Seo,SY Kim,KW Park,JY Kim,IY Jeong,MW Byun,JE Park,ST Yee,KH Kim,JS Rhim,K Yamada,KI Seo,

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Thiosulfinates from Allium tuberosum L. induce apoptosis via caspase-dependent and -independent pathways in PC-3 human prostate cancer cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 18

Page Numbers: 199-204

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 1464-3405

DAY: 30

MONTH: 10

YEAR: 2007

Thiosulfinates from Allium tuberosum L. induce apoptosis via caspase-dependent and -independent pathways in PC-3 human prostate cancer cells. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

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Grant and Affiliation Information for Thiosulfinates from Allium tuberosum L. induce apoptosis via caspase-dependent and -independent pathways in PC-3 human prostate cancer cells.

AFFILIATION: Department of Food and Nutrition, Sunchon National University, 315 Maegok, Suncheon, Jeonnam 540-742, Republic of Korea.

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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