Thigh muscle stiffness assessed with magnetic resonance elastography in hyperthyroid patients before and after medical treatment.

Thigh muscle stiffness assessed with magnetic resonance elastography in hyperthyroid patients before and after medical treatment. Research Abstract Details 

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Thigh muscle stiffness assessed with magnetic resonance elastography in hyperthyroid patients before and after medical treatment. Abstract Text:

Sabine F Bensamoun,Stacie I Ringleb,Qingshan Chen,Richard L Ehman,Kai-Nan An,Michael Brennan,

PURPOSE: To measure the stiffness of the vastus medialis (VM) in hyperthyroid patients before and after treatment. MATERIALS AND METHODS: A total of five healthy euthyroid patients and five hyperthyroid patients were tested using magnetic resonance elastography (MRE), which involves the induction of shear waves in the thigh muscles using a pneumatic driver at 90 Hz. RESULTS: Among the pretreatment hyperthyroid cohort a lower stiffness was found when the muscle was relaxed (2.11 +/- 0.61 kPa) compared the stiffness following treatment of hyperthyroidism (5.52 +/- 1.52 kPa), which was accompanied by an improvement in the contractile function of the VM. Pretreatment muscle stiffness was also less than that of age matched healthy volunteers (4.56 +/- 0.40 kPa). The behavior of the waves was sensitive to the stage of this myopathy and to the amount of free thyroxine (FT4). CONCLUSION: The MRE technique provides a new tool to gain new insights into pathophysiology of thyroid associated and other muscle diseases and their response to treatment.

Thigh muscle stiffness assessed with magnetic resonance elastography in hyperthyroid patients before and after medical treatment. Publishing Authors By Initials

SF Bensamoun,SI Ringleb,Q Chen,RL Ehman,KN An,M Brennan,

For similar hormones, hormone substitutes, and hormone antagonists: hormones: thyroid hormones: thyroxine research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: thyroid hormones: thyroxine research

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MEDLINE DATE:

Thigh muscle stiffness assessed with magnetic resonance elastography in hyperthyroid patients before and after medical treatment. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of magnetic resonance imaging : JMRI

VOLUME: 26

Page Numbers: 708-13

Journal Abbreviation:

ISSN: 1053-1807

DAY: 3

MONTH: Sep

YEAR: 2007

Thigh muscle stiffness assessed with magnetic resonance elastography in hyperthyroid patients before and after medical treatment. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9105850

Thigh muscle stiffness assessed with magnetic resonance elastography in hyperthyroid patients before and after medical treatment. Keywords Mesh Terms:

KEYWORDS: Thyroxine

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Thigh muscle stiffness assessed with magnetic resonance elastography in hyperthyroid patients before and after medical treatment. Information

Substance Name: Thyroxine

Registry Number: 7488-70-2

Grant and Affiliation Information for Thigh muscle stiffness assessed with magnetic resonance elastography in hyperthyroid patients before and after medical treatment.

AFFILIATION: Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, College of Medicine, Rochester, Minnesota, USA.

Country: United States

AGENCY: United States NICHD

GRANT: HD07447

ACRONYM: HD

MEDLINETA: J Magn Reson Imaging

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