Thiahomoisocitrate: A highly potent inhibitor of homoisocitrate dehydrogenase involved in the alpha-aminoadipate pathway.

Thiahomoisocitrate: A highly potent inhibitor of homoisocitrate dehydrogenase involved in the alpha-aminoadipate pathway. Research Abstract Details 

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Thiahomoisocitrate: A highly potent inhibitor of homoisocitrate dehydrogenase involved in the alpha-aminoadipate pathway. Abstract Text:

Takashi Yamamoto,Tadashi Eguchi,Takashi Yamamoto,Tadashi Eguchi,

Homoisocitrate dehydrogenase is involved in the alpha-aminoadipate pathway of l-lysine biosynthesis in higher fungi such as yeast and human pathogenic fungi. This enzyme catalyzes the oxidative decarboxylation of (2R,3S)-homoisocitrate into 2-ketoadipate using NAD(+) as a coenzyme. A series of aza-, oxa-, and thia-analogues of homoisocitrate was designed and synthesized as an inhibitor for homoisocitrate dehydrogenase. Among them, thia-analogue showed strong competitive inhibitory activity as K(i)=97nM toward homoisocitrate dehydrogenase derived from Saccharomyces cerevisiae. Kinetic studies suggested that the formation of the enolate intermediate played an important role in inhibition.

Thiahomoisocitrate: A highly potent inhibitor of homoisocitrate dehydrogenase involved in the alpha-aminoadipate pathway. Publishing Authors By Initials

T Yamamoto,T Eguchi,T Yamamoto,T Eguchi,

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Thiahomoisocitrate: A highly potent inhibitor of homoisocitrate dehydrogenase involved in the alpha-aminoadipate pathway. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry

VOLUME: 16

Page Numbers: 3372-6

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ISSN: 1464-3391

DAY: 8

MONTH: 12

YEAR: 2007

Thiahomoisocitrate: A highly potent inhibitor of homoisocitrate dehydrogenase involved in the alpha-aminoadipate pathway. Information

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LANGUAGE: eng

NlmUniqueID: 9413298

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Country: England

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