Thermotropic behavior and electronmicroscopic structures of mixtures of gangliosides and dipalmitoylphosphatidylcholine.

Thermotropic behavior and electronmicroscopic structures of mixtures of gangliosides and dipalmitoylphosphatidylcholine. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Thermotropic behavior and electronmicroscopic structures of mixtures of gangliosides and dipalmitoylphosphatidylcholine. Abstract Text:

H Kojima,K Hanada-Yoshikawa,A Katagiri,Y Tamai,

The calorimetric properties and morphological structures of dispersed mixtures of 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and highly purified human brain gangliosides, GM2, GM1, GD1a, GD1b, and GT1b, were studied using a high-sensitivity differential scanning calorimeter and an electron-microscope, as a function of the ganglioside molar fraction. No thermal phase transitions of pure gangliosides in aqueous dispersions could be detected. In the mixtures of DPPC and gangliosides, the gel to liquid crystalline phase transition occurred at a higher temperature than in pure DPPC dispersions and progressed over a wide temperature range. As increasing amounts of the pure ganglioside species were added to DPPC, the temperature for the main transition gradually increased. The phase transition progressed differently among different gangliosides/DPPC mixtures. The enthalpy values were found to decrease linearly as the number of sialic acid residues increased. Electron-microscopically the ganglioside/DPPC mixtures formed multilamellar structures at lower concentrations of the gangliosides, and the structures changed to cylindrical and spherical micelles as the ganglioside concentration was increased. The polysialoganglioside/DPPC mixtures showed the micellar form even at lower ganglioside concentrations, contrary to the case of the monosialoganglioside/DPPC mixtures. The morphological changes of gangliosides/DPPC mixtures corresponded with changes in the calorimetric properties. These results show that individual gangliosides have different physicochemical effects on model membranes, possibly because of the interaction of their negatively charged head groups.

Thermotropic behavior and electronmicroscopic structures of mixtures of gangliosides and dipalmitoylphosphatidylcholine. Publishing Authors By Initials

H Kojima,K Hanada-Yoshikawa,A Katagiri,Y Tamai,

For similar nervous system diseases: central nervous system diseases: brain diseases: brain diseases, metabolic: brain diseases, metabolic, inborn: lysosomal storage diseases, nervous system: sphingolipidoses: gangliosidoses: gangliosidoses, gm2: tay-sachs disease research abstracts see: nervous system diseases: central nervous system diseases: brain diseases: brain diseases, metabolic: brain diseases, metabolic, inborn: lysosomal storage diseases, nervous system: sphingolipidoses: gangliosidoses: gangliosidoses, gm2: tay-sachs disease research

PUBMED ID PMID:

MEDLINE DATE:

Thermotropic behavior and electronmicroscopic structures of mixtures of gangliosides and dipalmitoylphosphatidylcholine. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 103

Page Numbers: 126-31

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jan

YEAR: 1988

Thermotropic behavior and electronmicroscopic structures of mixtures of gangliosides and dipalmitoylphosphatidylcholine. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376600

Thermotropic behavior and electronmicroscopic structures of mixtures of gangliosides and dipalmitoylphosphatidylcholine. Keywords Mesh Terms:

KEYWORDS: Tay-Sachs Disease

MESH TERMS: metabolism

Chemical & Substance for Abstract: Thermotropic behavior and electronmicroscopic structures of mixtures of gangliosides and dipalmitoylphosphatidylcholine. Information

Substance Name: 1,2-Dipalmitoylphosphatidylcholine

Registry Number: 2644-64-6

Grant and Affiliation Information for Thermotropic behavior and electronmicroscopic structures of mixtures of gangliosides and dipalmitoylphosphatidylcholine.

AFFILIATION: Department of Biochemistry, Kitasato University School of Medicine, Kanagawa.

Country: JAPAN

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Biochem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Thermotropic behavior and electronmicroscopic structures of mixtures of gangliosides and dipalmitoylphosphatidylcholine Related Publications

• A novel fucosylated glycosphingolipid with a Gal beta 1-4Glc beta 1-3Gal sequence in plerocercoids of the parasite, Spirometra erinacei.
• Activation of ERK in the rostral ventromedial medulla is involved in hyperalgesia during peripheral inflammation.
• Axonal projections of single auditory neurons in the thalamic reticular nucleus: implications for tonotopy-related gating function and cross-modal modulation.
• BDNF increases the phagocytic activity in cultured iris pigment epithelial cells.
• Calcium ion dependent interaction of inorganic phosphorus compounds with phosphatidylcholine.
• Decreased biosynthesis of lung surfactant constituent phosphatidylcholine due to inhibition of choline transporter by gefitinib in lung alveolar cells.
• Edaravone prevents kainic acid-induced neuronal death.
• Effect of glucocorticoid receptor ligand dexamethasone on the expression of organic cation transporter in rat liver.
• Evidence of alpha-adrenoceptor-mediated chronotropic action in children.
• Expression of glycerol 3-phosphate dehydrogenase gene (CvGPD1) in salt-tolerant yeast Candida versatilis is stimulated by high concentrations of NaCl.
• Heterologous expression of Na+/H+ antiporter gene (CvNHA1) from salt-tolerant yeast Candida versatilis in Saccharomyces cerevisiae Na+-transporter deficient mutants.
• Influence of hospitalization on drug therapy in the elderly.
• Involvement of Uric Acid Transporters in Alteration of Serum Uric Acid Level by Angiotensin II Receptor Blockers.
• Involvement of organic anion transporting polypeptide 1a5 (oatp1a5) in the intestinal absorption of endothelin receptor antagonist in rats.
• Isolation of a subclonal cell line of PC12 transfected with dexamethasone-regulated ras oncogene: morphological differentiation, biochemical properties, and tumorigenicity.
• Isomerization of 11-cis-retinol to all-trans-retinol in bovine rod outer segments.
• Lengthening of short great toes by callus distraction.
• Magnetic resonance imaging of a non-pigmented adenoma of the ciliary epithelium.
• Malunited fractures of the distal radius treated with corrective osteotomy using volar locking plate and a corticocancellous bone graft following immediate mobilisation.
• Molecular cloning and sequencing of plasma membrane H(+)-ATPase gene from the salt-tolerant yeast Zygosaccharomyces rouxii.
• Persistent posterolateral rotatory subluxation of the elbow in cubitus varus: a case report.
• Predominant Contribution of Rat Organic Anion Transporting Polypeptide-2 (Oatp2) to Hepatic Uptake of beta-Lactam Antibiotics.
• Presence and connections of auditory neurons in the rostrodorsal and rostrolateral parts of the thalamic reticular nucleus.
• Purification and some properties of membrane-bound phospholipase B from Torulaspora delbrueckii.
• Subtalar arthrography in acute injuries of the calcaneofibular ligament.
• Tarsal tunnel syndrome. Causes and results of operative treatment.
• Thermotropic behavior and electronmicroscopic structures of mixtures of gangliosides and dipalmitoylphosphatidylcholine.
• Variant autonomic regulation during active standing in Swedish and Japanese junior high school children.
• [A case of bilateral synchronous primary lung cancer treated by two-staged bilateral bronchoplastic procedures]
• [Prognosis and therapy of adult acute leukemia with 11q23 abnormalities]