Thermoresponsive nanostructures by self-assembly of a poly(N-isopropylacrylamide)-lipid conjugate.

Thermoresponsive nanostructures by self-assembly of a poly(N-isopropylacrylamide)-lipid conjugate. Research Abstract Details 

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Thermoresponsive nanostructures by self-assembly of a poly(N-isopropylacrylamide)-lipid conjugate. Abstract Text:

Daniel N T Hay,Paul G Rickert, Seifert,Millicent A Firestone,

The synthesis and purification of a poly(N-isopropylacrylamide)-lipid conjugate and its use in the preparation of a thermoresponsive lipid mesophase is described. Specifically, poly(N-isopropylacrylamide) with a single carboxyl group at one end was activated with dicyclohexylcarbodiimide/N-hydroxysuccinimide to form an active ester. This N-hydroxysuccinimide ester was then used to form a dimyristoyl-sn-glycero-3-phosphoethanolamine conjugate with poly(N-isopropylacrylamide) via an amide bond, rendering the conjugate amphiphilic. Quaternary phases comprising the conjugate, a phosopholipid, dimyristoylphosphatidylcholine, and a cosurfactant, N,N-dimethyldodecylamine-N-oxide, dispersed in water were found to self-assemble at room temperature to form liquid crystalline gels, adopting an expanded lamellar structure. A modest increase in temperature triggered the reversible conversion of the aggregate to a collapsed lamellar structure, while a modest reduction in temperature resulted in its conversion to a nonlamellar phase. The phases were characterized by polarized optical microscopy and small-angle X-ray scattering (SAXS).

Thermoresponsive nanostructures by self-assembly of a poly(N-isopropylacrylamide)-lipid conjugate. Publishing Authors By Initials

DN Hay,PG Rickert,S Seifert,MA Firestone,

For similar natural sciences: physics: radiation: radiation, ionizing: x-rays research abstracts see: natural sciences: physics: radiation: radiation, ionizing: x-rays research

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Thermoresponsive nanostructures by self-assembly of a poly(N-isopropylacrylamide)-lipid conjugate. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 126

Page Numbers: 2290-1

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 3

MONTH: Mar

YEAR: 2004

Thermoresponsive nanostructures by self-assembly of a poly(N-isopropylacrylamide)-lipid conjugate. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Thermoresponsive nanostructures by self-assembly of a poly(N-isopropylacrylamide)-lipid conjugate. Keywords Mesh Terms:

KEYWORDS: X-Rays

MESH TERMS: chemistry

Chemical & Substance for Abstract: Thermoresponsive nanostructures by self-assembly of a poly(N-isopropylacrylamide)-lipid conjugate. Information

Substance Name: poly-N-isopropylacrylamide

Registry Number: 25189-55-3

Grant and Affiliation Information for Thermoresponsive nanostructures by self-assembly of a poly(N-isopropylacrylamide)-lipid conjugate.

AFFILIATION: Materials Science, Chemistry, Argonne National Laboratory, Argonne, Illinois 60439, USA.

Country: United States

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MEDLINETA: J Am Chem Soc

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