Thermodynamic properties of enzyme-catalyzed reactions involving cytosine, uracil, thymine, and their nucleosides and nucleotides.

Thermodynamic properties of enzyme-catalyzed reactions involving cytosine, uracil, thymine, and their nucleosides and nucleotides. Research Abstract Details 

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Thermodynamic properties of enzyme-catalyzed reactions involving cytosine, uracil, thymine, and their nucleosides and nucleotides. Abstract Text:

Robert A Alberty,

The standard Gibbs energies of formation of species in the cytidine triphosphate series, uridine triphosphate series, and thymidine triphosphate series have been calculated on the basis of the convention that Delta(f)G=0 for the neutral form of cytidine in aqueous solution at 298.15 K at zero ionic strength. This makes it possible to calculate apparent equilibrium constants for a number of reactions for which apparent equilibrium constants have not been measured or cannot be measured because they are too large. This paper adds fifteen reactants to the database BasicBiochemData3 at MathSource that includes 199 reactants. The standard transformed Gibbs energies of formation of these fifteen reactants are used to calculate apparent equilibrium constants at 298.15 K, ionic strength 0.25 M, and pHs 5, 6, 7, 8, and 9 for thirty two reactions. The pKs, standard Gibbs energies of hydrolysis, and standard Gibbs energies of deamination are given for these fifteen reactants.

Thermodynamic properties of enzyme-catalyzed reactions involving cytosine, uracil, thymine, and their nucleosides and nucleotides. Publishing Authors By Initials

RA Alberty,

For similar heterocyclic compounds: heterocyclic compounds, 1-ring: pyrimidines: pyrimidinones: uracil research abstracts see: heterocyclic compounds: heterocyclic compounds, 1-ring: pyrimidines: pyrimidinones: uracil research

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MEDLINE DATE:

Thermodynamic properties of enzyme-catalyzed reactions involving cytosine, uracil, thymine, and their nucleosides and nucleotides. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biophysical chemistry

VOLUME: 127

Page Numbers: 91-6

Journal Abbreviation: Biophys. Chem.

ISSN: 0301-4622

DAY: 22

MONTH: 01

YEAR: 2007

Thermodynamic properties of enzyme-catalyzed reactions involving cytosine, uracil, thymine, and their nucleosides and nucleotides. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 403171

Thermodynamic properties of enzyme-catalyzed reactions involving cytosine, uracil, thymine, and their nucleosides and nucleotides. Keywords Mesh Terms:

KEYWORDS: Uracil

MESH TERMS: chemistry

Chemical & Substance for Abstract: Thermodynamic properties of enzyme-catalyzed reactions involving cytosine, uracil, thymine, and their nucleosides and nucleotides. Information

Substance Name: Cytosine

Registry Number: 71-30-7

Grant and Affiliation Information for Thermodynamic properties of enzyme-catalyzed reactions involving cytosine, uracil, thymine, and their nucleosides and nucleotides.

AFFILIATION: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, United States. alberty@mit.edu

Country: Netherlands

AGENCY: United States NIGMS

GRANT: R01 GM048358-09

ACRONYM: GM

MEDLINETA: Biophys Chem

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