Thermal neutron irradiation field design for boron neutron capture therapy of human explanted liver.

Thermal neutron irradiation field design for boron neutron capture therapy of human explanted liver. Research Abstract Details 

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Thermal neutron irradiation field design for boron neutron capture therapy of human explanted liver. Abstract Text:

S Bortolussi,S Altieri,S Bortolussi,S Altieri,

The selective uptake of boron by tumors compared to that by healthy tissue makes boron neutron capture therapy (BNCT) an extremely advantageous technique for the treatment of tumors that affect a whole vital organ. An example is represented by colon adenocarcinoma metastases invading the liver, often resulting in a fatal outcome, even if surgical resection of the primary tumor is successful. BNCT can be performed by irradiating the explanted organ in a suitable neutron field. In the thermal column of the Triga Mark II reactor at Pavia University, a facility was created for this purpose and used for the irradiation of explanted human livers. The neutron field distribution inside the organ was studied both experimentally and by means of the Monte Carlo N-particle transport code (MCNP). The liver was modeled as a spherical segment in MCNP and a hepatic-equivalent solution was used as an experimental phantom. In the as-built facility, the ratio between maximum and minimum flux values inside the phantom ((phi(max)/phi(min)) was 3.8; this value can be lowered to 2.3 by rotating the liver during the irradiation. In this study, the authors proposed a new facility configuration to achieve a uniform thermal neutron flux distribution in the liver. They showed that a phi(max)/phi(min) ratio of 1.4 could be obtained without the need for organ rotation. Flux distributions and dose volume histograms were reported for different graphite configurations.

Thermal neutron irradiation field design for boron neutron capture therapy of human explanted liver. Publishing Authors By Initials

S Bortolussi,S Altieri,S Bortolussi,S Altieri,

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Thermal neutron irradiation field design for boron neutron capture therapy of human explanted liver. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Medical physics

VOLUME: 34

Page Numbers: 4700-5

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ISSN: 0094-2405

DAY: 16

MONTH: Dec

YEAR: 2007

Thermal neutron irradiation field design for boron neutron capture therapy of human explanted liver. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Thermal neutron irradiation field design for boron neutron capture therapy of human explanted liver.

AFFILIATION: Department of Nuclear and Theoretical Physics, University of Pavia, INFN Section of Pavia, via Bassi 6, 27100 Pavia, Italy. silva.bortolussi@pv.infn.it

Country: United States

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MEDLINETA: Med Phys

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