Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow.

Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow. Research Abstract Details 

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Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow. Abstract Text:

M Feuerer,P Beckhove,L Bai,E F Solomayer,I J Diel,C Pedain,M Oberniedermayr,V Schirrmacher,V Umansky,

In an analysis of 84 primary-operated breast cancer patients and 11 healthy donors, we found that the bone marrow of most patients contained memory T cells with specificity for tumor-associated antigens. Patients' bone marrow and peripheral blood contained CD8+ T cells that specifically bound HLA/peptide tetramers. In short-term culture with autologous dendritic cells pre-pulsed with tumor lysates, patients' memory T cells from bone marrow (but not peripheral blood) could be specifically reactivated to interferon-gamma-producing and cytotoxic effector cells. A single transfer of restimulated bone-marrow T cells into NOD/SCID mice caused regression of autologous tumor xenotransplants associated with infiltration by human T cells and tumor-cell apoptosis and necrosis. T cells from peripheral blood showed much lower anti-tumor reactivity. Our findings reveal an innate, specific recognition of breast cancer antigens and point to a possible novel cancer therapy using patients' bone-marrow-derived memory T cells.

Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow. Publishing Authors By Initials

M Feuerer,P Beckhove,L Bai,EF Solomayer,IJ Diel,C Pedain,M Oberniedermayr,V Schirrmacher,V Umansky,

For similar surgical procedures, operative: transplantation: transplantation, heterologous research abstracts see: surgical procedures, operative: transplantation: transplantation, heterologous research

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Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature medicine

VOLUME: 7

Page Numbers: 452-8

Journal Abbreviation: Nat. Med.

ISSN: 1078-8956

DAY: 1

MONTH: Apr

YEAR: 2001

Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow. Information

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LANGUAGE: eng

NlmUniqueID: 9502015

Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow. Keywords Mesh Terms:

KEYWORDS: Transplantation, Heterologous

MESH TERMS: immunology

Chemical & Substance for Abstract: Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow. Information

Substance Name: Receptor, erbB-2

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow.

AFFILIATION: Division of Cellular Immunology, Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany.

Country: United States

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MEDLINETA: Nat Med

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