Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body.

Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body. Abstract Text:

Bronwen Martin,Erin Golden,Alex Keselman,Matthew Stone,Mark P Mattson,Josephine M Egan,Stuart Maudsley,Bronwen Martin,Erin Golden,Alex Keselman,Matthew Stone,Mark P Mattson,Josephine M Egan,Stuart Maudsley,

Huntington's disease (HD) is a tremendously debilitating disorder that strikes relatively young individuals and progresses rapidly over the next ten to fifteen years inducing a loss of cognitive and motor skills and eventually death occurs. The primary locus of the disorder is a polyglutamine expansion of the protein product of the huntingtin (htt) gene. The htt protein appears to be a scaffolding protein that orchestrates the complex assembly of multiple intracellular proteins involved in multiple processes, including vesicular movement and cell metabolism. The htt protein is ubiquitously expressed in human tissues but the predominance of the interest in the pathology lies in its effects on the central nervous system (CNS). Most of the current therapeutics for HD thus have been targeted at preventing neuronal damage in the CNS, however, a considerable body of evidence has been accumulating to suggest that the maintenance of a healthy nervous system is tightly linked with peripheral physiological health. Therefore treatment of both the peripheral and central pathophysiologies of HD could form the basis of a more effective HD therapeutic strategy.

Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body. Publishing Authors By Initials

B Martin,E Golden,A Keselman,M Stone,MP Mattson,JM Egan,S Maudsley,B Martin,E Golden,A Keselman,M Stone,MP Mattson,JM Egan,S Maudsley,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Histology and histopathology

VOLUME: 23

Page Numbers: 237-50

Journal Abbreviation:

ISSN: 1699-5848

DAY: 13

MONTH: Feb

YEAR: 2008

Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8609357

Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body.

AFFILIATION: National Institute on Aging, NIH, Gerontology Research Center, Baltimore, MD 21224, USA.

Country: Spain

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Histol Histopathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body Related Publications

• A case of myositis ossificans progressiva.
• A functional outpatient desk.
• Assessment of international medical graduates and their integration into family practice: the clinician assessment for practice program.
• Caloric restriction: Impact upon pituitary function and reproduction.
• Can MR spectroscopy ever be simple and effective?
• Charcot joints in diabetic neuropathy.
• Cytoskeletal reorganization dependence of signaling by the gonadotropin-releasing hormone receptor.
• Dysplasia epiphysialis multiplex; a report of fourteen cases in three families.
• Fatigue fractures of the lower tibia; a report of five cases.
• GAVA: spectral simulation for in vivo MRS applications.
• GnRH-mediated DAN production regulates the transcription of the GnRH receptor in gonadotrope cells.
• Gonadotropin-releasing hormone receptors.
• Gonadotropin-releasing hormone-induced activation of diacylglycerol kinase-zeta and its association with active c-src.
• Henery fitzgerald MAUDSLEY.
• Improved reconstruction for MR spectroscopic imaging.
• Instillation-suction technique in chronic osteomyelitis.
• Lightning accident at Ascot.
• Proceedings: Post-operative gas gangrene managed by hyperbaric oxygen.
• Radial tunnel syndrome: resistant tennis elbow as a nerve entrapment.
• Some ideals for a psychiatric service.
• Targeting TNF-alpha receptors for neurotherapeutics.
• The management of gas gangrene with hyperbaric oxygen therapy.
• Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body.
• iTRAQ Analysis of Complex Proteome Alterations in 3xTgAD Alzheimer's Mice: Understanding the Interface between Physiology and Disease.