Therapeutic leukocytapheresis for inflammatory bowel disease.

Therapeutic leukocytapheresis for inflammatory bowel disease. Research Abstract Details 

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Therapeutic leukocytapheresis for inflammatory bowel disease. Abstract Text:

Abbi R Saniabadi,Hiroyuki Hanai,Ken Fukunaga,Koji Sawada,Chikako Shima,Ingvar Bjarnason,Robert Lofberg,Abbi R Saniabadi,Hiroyuki Hanai,Ken Fukunaga,Koji Sawada,Chikako Shima,Ingvar Bjarnason,Robert Lofberg,

The inference that granulocytes and monocytes/macrophages (GM) are part of the immunopathogenesis of inflammatory bowel disease (IBD) and hence should be targets of therapy stems from observations of elevated, and activated GM in patients with IBD. The Adacolumn can selectively deplete GM by adsorption (GMA) and in patients with IBD, GMA has been associated with significant clinical efficacy together with sustained suppression of inflammatory cytokine profiles. Additionally, GMA depleted proinflammatory CD14(+)CD16(+) monocytes and was followed by an increase in CD4(+) T lymphocytes including the regulatory CD4(+)CD25(high+)Foxp3 phenotype. Hence, GMA could be a non-pharmacologic therapy for IBD with potential to spare steroids and other unsafe pharmacologic preparations.

Therapeutic leukocytapheresis for inflammatory bowel disease. Publishing Authors By Initials

AR Saniabadi,H Hanai,K Fukunaga,K Sawada,C Shima,I Bjarnason,R Lofberg,AR Saniabadi,H Hanai,K Fukunaga,K Sawada,C Shima,I Bjarnason,R Lofberg,

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Therapeutic leukocytapheresis for inflammatory bowel disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Transfusion and apheresis science : official journ

VOLUME: 37

Page Numbers: 191-200

Journal Abbreviation: Transfus. Apher. Sci.

ISSN: 1473-0502

DAY: 31

MONTH: 10

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 101095653

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AFFILIATION: JIMRO Laboratories, 351-1 Nishiyokote Machi, Takasaki, Japan. saniabadi@jimro.co.jp

Country: England

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MEDLINETA: Transfus Apher Sci

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