Therapeutic efficacy of basic fibroblast growth factor on experimental focal ischemia studied by magnetic resonance imaging.

Therapeutic efficacy of basic fibroblast growth factor on experimental focal ischemia studied by magnetic resonance imaging. Research Abstract Details 

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Therapeutic efficacy of basic fibroblast growth factor on experimental focal ischemia studied by magnetic resonance imaging. Abstract Text:

Kolammal Nageswari,Shigenori Mizusawa,Yasushi Kondoh,Kazuhiro Nakamura,Iwao Kanno,

The purpose of this study was to evaluate the effect of intravenous infusion of basic fibroblast growth factor (bFGF) in a permanent ischemia model at the subacute phase (2 weeks) as well as at 24 hours and 1 week using T(2)-weighted magnetic resonance imaging (MRI). The middle cerebral artery (MCA) in Sprague-Dawley rats was occluded using an intraluminal suture method. The rats were randomly divided into 2 groups to receive either bFGF (45 mug/kg/hr) or saline solution. The infusion was started 30 minutes after MCA occlusion (MCAO) and continued for 3 hours. Regional cerebral blood flow (rCBF) was measured using laser Doppler flowmetry throughout the infusion. T(2)-weighted MRI was carried out before MCAO, 24 hours after MCAO, and days 7 and 14 after MCAO. Although an elevation in rCBF was seen after the infusion, no significant change between the groups was observed. A significant difference between the bFGF and saline groups in T(2)-derived lesion volume was observed at 24 hours (P < .05), on day 7 (P < .05), and on day 14 (P < .01). The percentage of lesion area calculated from the ipsilateral hemisphere using hematoxylin and eosin staining on day 14 showed a significant difference between the bFGF and saline groups (P < .05). No significant change in the number of bromodeoxyuridine (BrdU)-labeled cells between the groups was observed. This study demonstrates that bFGF, infused intravenously starting 30 minutes after the induction of permanent MCAO, significantly reduces region volume even at day 14, as well as at days 1 and 7, compared with the corresponding saline group.

Therapeutic efficacy of basic fibroblast growth factor on experimental focal ischemia studied by magnetic resonance imaging. Publishing Authors By Initials

K Nageswari,S Mizusawa,Y Kondoh,K Nakamura,I Kanno,

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Therapeutic efficacy of basic fibroblast growth factor on experimental focal ischemia studied by magnetic resonance imaging. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of stroke and cerebrovascular diseases : t

VOLUME: 14

Page Numbers: 187-92

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ISSN: 1532-8511

DAY: 1

MONTH: 10

YEAR: 2007

Therapeutic efficacy of basic fibroblast growth factor on experimental focal ischemia studied by magnetic resonance imaging. Information

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LANGUAGE: eng

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AFFILIATION: Department of Internal Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan; School of Biosciences and Bioengineering, Indian Institute of Technology, Bombay, Powai, India.

Country: United States

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MEDLINETA: J Stroke Cerebrovasc Dis

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