Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model.

Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model. Abstract Text:

Yubin Miao,Tiffani Shelton,Thomas P Quinn,

The aim of this study was to examine the therapeutic efficacy of (177)Lu-DOTA-Re(Arg(11))CCMSH in the B16/F1 murine melanoma-bearing mouse model. METHODS: (177)Lu-DOTA-Re(Arg(11))CCMSH was prepared in 0.5 M NH(4)OAc at a pH of 5.4. Two (2) treatment groups of 10 melanoma-bearing C57 mice were administrated with 2 x 18.5 MBq and 1 x 37.0 MBq of (177)Lu-DOTA-Re(Arg(11))CCMSH through the tail vein, respectively. One (1) group of 10 melanoma-bearing C57 mice was injected with saline placebos as untreated melanoma-bearing controls. RESULTS: In contrast to the untreated melanoma-bearing control group, (177)Lu-DOTA-Re(Arg(11))CCMSH administration yielded rapid and lasting therapeutic effects in the treatment groups. (177)Lu-DOTA-Re(Arg(11))CCMSH treatment decreased the tumor growth rate and significantly (p > 0.05) prolonged the survival time of melanoma-bearing C57 mice. Treatment with 2 x 18.5 MBq or 1 x 37.0 MBq of (177)Lu-DOTA-Re(Arg(11))CCMSH significantly extended the mean survival of tumor-bearing mice from 13.3 to 15.1 and 16.2 days, respectively. (177)Lu-DOTA-Re(Arg(11))CCMSH treatment produced no observed acute renal toxicity. CONCLUSIONS: The therapy study results revealed that (177)Lu-DOTA-Re(Arg(11))CCMSH yielded quantitative therapeutic effects in B16/F1 melanoma-bearing mice and appeared to be a promising radiolabeled peptide for the targeted radionuclide therapy of melanoma.

Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model. Publishing Authors By Initials

Y Miao,T Shelton,TP Quinn,

For similar hormones, hormone substitutes, and hormone antagonists: hormones: peptide hormones: hypothalamic hormones: pro-opiomelanocortin: alpha-msh research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: peptide hormones: hypothalamic hormones: pro-opiomelanocortin: alpha-msh research

PUBMED ID PMID:

MEDLINE DATE:

Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cancer biotherapy & radiopharmaceuticals

VOLUME: 22

Page Numbers: 333-41

Journal Abbreviation: Cancer Biother. Radiopharm.

ISSN: 1084-9785

DAY: 3

MONTH: Jun

YEAR: 2007

Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9605408

Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model. Keywords Mesh Terms:

KEYWORDS: alpha-MSH

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model. Information

Substance Name: Lutetium

Registry Number: 7439-94-3

Grant and Affiliation Information for Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model.

AFFILIATION: College of Pharmacy, University of New Mexico, Albuquerque, NM, USA.

Country: United States

AGENCY: United States NCI

GRANT: P50-CA-103130

ACRONYM: CA

MEDLINETA: Cancer Biother Radiopharm

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model Related Publications

• A role for eyebrows in regulating the visibility of eye gaze direction.
• Alpha-melanocyte stimulating hormone peptide-targeted melanoma imaging.
• Comments on the analysis of some triacid triglyceride mixtures.
• Comparative efficacy of nucleoside/nucleotide reverse transcriptase inhibitors in combination with efavirenz: results of a systematic overview.
• Contact Lenses in Pediatrics (CLIP) Study: chair time and ocular health.
• Epithelial-mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: an exception to the norm.
• Gender and cleaner production: toward a framework for including gender analysis when developing strategies and designing solutions.
• Generation of a transgenic model to address regulation and function of the human neurokinin 1 receptor (NK1R).
• High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl peptide receptor agonists.
• Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems.
• Infants' sensitivity to uniform connectedness as a cue for perceptual organization.
• Melanoma imaging with pretargeted bivalent bacteriophage.
• N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.
• Nitric oxide-NGF mediated PPTA/SP, ADNP, and VIP expression in the peripheral nervous system.
• Osteoclast inhibitory lectin (OCIL) inhibits osteoblast differentiation and function in vitro.
• Passivating protein coatings for implantable glucose sensors: evaluation of protein retention.
• Pharmacological treatment of heart failure.
• Reducing health disparities in depressive disorders outcomes between non-Hispanic Whites and ethnic minorities: a call for pragmatic strategies over the life course.
• Reducing renal uptake of 90Y- and 177Lu-labeled alpha-melanocyte stimulating hormone peptide analogues.
• Retinopathy of prematurity in Brazil: an emerging problem.
• Review: advance provision of emergency contraception increases its use but does not reduce unplanned pregnancies.
• Role of NF-kappaB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-alpha.
• Spina bifida advocacy--a case study in public policy success.
• Systemic reaction rates to field stings among imported fire ant-sensitive patients receiving >3 years of immunotherapy versus <3 years of immunotherapy.
• The future in advanced prostate cancer: take your partners or is the last dance for me?
• The purification and specificity of a lipase fromVernonia anthelmintica seed.
• Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model.
• Trachoma and ocular Chlamydia trachomatis were not eliminated three years after two rounds of mass treatment in a trachoma hyperendemic village.
• Trench entrapment: is ketamine safe to use for sedation in head injury?
• Uterine innervation in fibroids: a qualitative study.