Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model.

Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model. Abstract Text:

H Hasegawa,A Inoue,M Kohno,J Lei,T Miyazaki,O Yoshie,M Nose,M Yasukawa,H Hasegawa,A Inoue,M Kohno,J Lei,T Miyazaki,O Yoshie,M Nose,M Yasukawa,

Adoptive transfer of CD4(+)CD25(+) regulatory T cells has been shown to have therapeutic effects in experimental graft-vs-host disease (GVHD) models. Chemokines play an important role in the recruitment of alloreactive donor T cells into target organs during GVHD. In this study, we investigated the effectiveness of targeted delivery of CD4(+)CD25(+) regulatory T cells via a transfected chemokine receptor on reduction of organ damage during acute GVHD. High levels of expression of Th1-associated chemokines (CXCL9, CXCL10 and CXCL11) and their receptor CXCR3 were observed in the liver, lung and intestine of GVHD-induced recipient mice. Recipient mice that had undergone transfer of CD4(+)CD25(+)Foxp3(+) CXCR3-transfected T cells (CXCR3-Treg cells) showed significant amelioration of GVHD changes in the liver, lung and intestine in comparison with recipient mice that had received CD4(+)CD25(+)Foxp3(+) T cells (Treg cells) or naturally occurring CD4(+)CD25(+) regulatory T cells. This was due to more pronounced migration of CXCR3-Treg cells and their localization for a longer time in Th1-associated chemokine-expressing organs, resulting in stronger suppressive activity. We succeeded in preparing chemokine receptor-expressing Treg cells and demonstrated their ability to ameliorate disease progression upon accumulation in target organs. This method may provide a new therapeutic approach for organ damage in acute GVHD.Gene Therapy (2008) 15, 171-182; doi:10.1038/sj.gt.3303051; published online 8 November 2007.

Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model. Publishing Authors By Initials

H Hasegawa,A Inoue,M Kohno,J Lei,T Miyazaki,O Yoshie,M Nose,M Yasukawa,H Hasegawa,A Inoue,M Kohno,J Lei,T Miyazaki,O Yoshie,M Nose,M Yasukawa,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Gene therapy

VOLUME: 15

Page Numbers: 171-82

Journal Abbreviation: Gene Ther.

ISSN: 0969-7128

DAY: 8

MONTH: 11

YEAR: 2007

Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9421525

Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model.

AFFILIATION: 1Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Ehime, Japan.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Gene Ther

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model Related Publications

• 18-year recurrence-free survival after extensive surgery for kidney cancer with atrial tumor thrombi.
• Analysis of Sir2E in the cellular slime mold Dictyostelium discoideum: cellular localization, spatial expression and overexpression.
• Cooperative Role of the Membrane-proximal and -distal Residues of the Integrin {beta}3 Cytoplasmic Domain in Regulation of Talin-mediated {alpha}IIb{beta}3 Activation.
• Effects of neutral salts and alcohols on the activity of Streptomyces caespitosus neutral protease.
• Engineering, expression, purification, and production of recombinant thermolysin.
• Expression of recombinant human glutamic acid decarboxylase (GAD) in myeloma cells and enzyme-linked immunosorbent assay (ELISA) for autoantibodies to GAD.
• Expression of recombinant human thyrotropin receptor in myeloma cells.
• Identification of an epitope derived from CML66, a novel tumor-associated antigen expressed broadly in human leukemia, recognized by human leukocyte antigen-A*2402-restricted cytotoxic T lymphocytes.
• Improvement in performance of affinity gels containing Gly-D-Phe as a ligand to thermolysin due to increasing the spacer chain length.
• New Cytotoxic Diarylheptanoids from the Rhizomes of Alpinia officinarum.
• New anti-inflammatory ergostane-type ecdysteroids from the sclerotium of Polyporus umbellatus.
• Preparation of mouse-human chimeric antibody to an embryonic carbohydrate antigen, Lewis Y.
• Purification to homogeneity of a neutral metalloproteinase from Streptomyces caespitosus.
• Sexual selection and red-winged blackbirds.
• Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model.
• [Basis of malignant lymphoma. 3. Etiological mechanism (infection)]
• [Cellular immunotherapy for hematological malignancies]
• [Human herpesvirus 6 in hematological diseases]