Theoretical MRI contrast model for exogenous T2 agents.

Theoretical MRI contrast model for exogenous T2 agents. Research Abstract Details 

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Theoretical MRI contrast model for exogenous T2 agents. Abstract Text:

Parker H Mills,Eric T Ahrens,

The rational development of new generations of MRI contrast agents (CAs) requires a scheme for predicting contrast enhancement. Previous contrast predictions have been based largely on empirical results in specific systems. Here we present a general theoretical model for evaluating the minimum concentration of T2 CA required for satisfactory image contrast. This analytic contrast model is applicable to a wide range of T2-type agents and delivery scenarios, and requires only a few readily evaluated parameters. We demonstrated the model by predicting contrast produced by superparamagnetic ferumoxide and the iron storage protein, ferritin. We then experimentally verified the predictions using suspensions of Feridex(R) and ferritin in phantoms. The model was also used to compare the contrast efficacy of the metal ions in two clinically approved T1- and T2-type CAs. In the Appendix we present a numerical formalism that is useful for relating image contrast and agent concentration when gradient-echo (GRE) T2*-weighted (T2*W) pulse sequences are used.

Theoretical MRI contrast model for exogenous T2 agents. Publishing Authors By Initials

PH Mills,ET Ahrens,

For similar equipment and supplies: phantoms, imaging research abstracts see: equipment and supplies: phantoms, imaging research

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MEDLINE DATE:

Theoretical MRI contrast model for exogenous T2 agents. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Magnetic resonance in medicine : official journal

VOLUME: 57

Page Numbers: 442-7

Journal Abbreviation:

ISSN: 0740-3194

DAY: 3

MONTH: Feb

YEAR: 2007

Theoretical MRI contrast model for exogenous T2 agents. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8505245

Theoretical MRI contrast model for exogenous T2 agents. Keywords Mesh Terms:

KEYWORDS: Phantoms, Imaging

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Theoretical MRI contrast model for exogenous T2 agents. Information

Substance Name: Ferritins

Registry Number: 9007-73-2

Grant and Affiliation Information for Theoretical MRI contrast model for exogenous T2 agents.

AFFILIATION: Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA.

Country: United States

AGENCY: United States PHS

GRANT: R01-EBG005740

ACRONYM: ES

MEDLINETA: Magn Reson Med

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