Theophylline affects sleep-wake state development in premature infants.

Theophylline affects sleep-wake state development in premature infants. Research Abstract Details 

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Theophylline affects sleep-wake state development in premature infants. Abstract Text:

E B Thoman,D H Davis,J R Raye,A F Philipps,J C Rowe,V H Denenberg,E B Thoman,D H Davis,J R Raye,A F Philipps,J C Rowe,V H Denenberg,

This study investigated the prolonged effects on state behavior of theophylline administered to infants for apnea of prematurity. There were three groups: Four premature infants who had received theophylline in the preterm period, five premature infants who had not received theophylline, and twenty-eight normal fullterm infants. The Theophylline infants had been off the drug for at least one month prior to the beginning of the study. Sleep-wake states were observed in the home for seven-hour periods when all infants were the same corrected ages: two, three, four and five weeks post-term. Data from the portion of the day that the infants were alone were analysed for this study. The state organization of the Theophylline group differed significantly from those of the other groups. They exhibited more non-alert waking activity, more alert, more drowse or transition, and less active sleep than did the Non-Theophylline and Fullterm infants. The state distributions of the latter two groups did not differ. On the basis of similarities between the results of this study and of a previous animal study, it was concluded that theophylline altered the normal development of state organization in premature infants. These effects persisted long after the drug had cleared the body.

Theophylline affects sleep-wake state development in premature infants. Publishing Authors By Initials

EB Thoman,DH Davis,JR Raye,AF Philipps,JC Rowe,VH Denenberg,EB Thoman,DH Davis,JR Raye,AF Philipps,JC Rowe,VH Denenberg,

For similar heterocyclic compounds: alkaloids: xanthines: theophylline research abstracts see: heterocyclic compounds: alkaloids: xanthines: theophylline research

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Theophylline affects sleep-wake state development in premature infants. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Neuropediatrics

VOLUME: 16

Page Numbers: 13-8

Journal Abbreviation: Neuropediatrics

ISSN: 0174-304X

DAY: 16

MONTH: Feb

YEAR: 1985

Theophylline affects sleep-wake state development in premature infants. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8101187

Theophylline affects sleep-wake state development in premature infants. Keywords Mesh Terms:

KEYWORDS: Theophylline

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Theophylline affects sleep-wake state development in premature infants. Information

Substance Name: Theophylline

Registry Number: 58-55-9

Grant and Affiliation Information for Theophylline affects sleep-wake state development in premature infants.

AFFILIATION:

Country: GERMANY, WEST

AGENCY: United States PHS

GRANT: MCJ-090480

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MEDLINETA: Neuropediatrics

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