The zinc finger protein A20 protects endothelial cells from burns serum injury.

The zinc finger protein A20 protects endothelial cells from burns serum injury. Research Abstract Details 

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The zinc finger protein A20 protects endothelial cells from burns serum injury. Abstract Text:

Chu-Hong Zhu,Da-Jun Ying,Jian-Hong Mi,Wei Zhang,Shi-Wu Dong,Jian-Sen Sun,Jia-Ping Zhang,

Burn injuries as well as skin damages are often associated with immune suppression and often cause multiple organ failures. The monolayer endothelium is vulnerable to injuries from circulating factors resulting from remote wounds. Endothelial cell activation and apoptosis can alter microvascular permeability and intensify organ damage. A20, as a physiological cytoprotective gene is essential for preventing spontaneous innate immune cell-mediated inflammation and tissue destruction. It is not known whether A20 has the function to protect endothelial cells from the effect of burns serum challenge on endothelial function in vitro. This study shows that A20 can express in endothelial cells after burns serum stimulation and inhibit endothelial cell activation and apoptosis induced by burns serum. These results suggest that A20 may be beneficial in limiting the response to burn injuries.

The zinc finger protein A20 protects endothelial cells from burns serum injury. Publishing Authors By Initials

CH Zhu,DJ Ying,JH Mi,W Zhang,SW Dong,JS Sun,JP Zhang,

For similar zinc fingers research abstracts see: zinc fingers research

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The zinc finger protein A20 protects endothelial cells from burns serum injury. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Burns : journal of the International Society for B

VOLUME: 30

Page Numbers: 127-33

Journal Abbreviation:

ISSN: 0305-4179

DAY: 9

MONTH: Mar

YEAR: 2004

The zinc finger protein A20 protects endothelial cells from burns serum injury. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8913178

The zinc finger protein A20 protects endothelial cells from burns serum injury. Keywords Mesh Terms:

KEYWORDS: Zinc Fingers

MESH TERMS: physiology

Chemical & Substance for Abstract: The zinc finger protein A20 protects endothelial cells from burns serum injury. Information

Substance Name: TNFAIP3 protein, human

Registry Number: EC 6.3.2.19

Grant and Affiliation Information for The zinc finger protein A20 protects endothelial cells from burns serum injury.

AFFILIATION: Department of Anatomy, The Key Lab of Biomechanics under the Ministry, The Third Military Medical University, Gao Tan Yan Street, Shaping Ba District, Chongqing 400038, China.

Country: England

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MEDLINETA: Burns

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