The zinc-binding protein chordc1 undergoes complex diurnal changes in mRNA expression during mouse brain development.

The zinc-binding protein chordc1 undergoes complex diurnal changes in mRNA expression during mouse brain development. Research Abstract Details 

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The zinc-binding protein chordc1 undergoes complex diurnal changes in mRNA expression during mouse brain development. Abstract Text:

Jason R Gerstner,Charles F Landry,

Diurnal changes in Chordc1 mRNA were recently described in mouse hypothalamus. This report shows that Chordc1 mRNA changes rhythmically throughout the entire adult brain with highest expression levels occurring around the dark-light transition. The rhythmic cycling pattern of Chordc1 was retained under various light-dark schedules and analysis of adult whole brain revealed diurnal patterns that were different than young animals (postnatal day (P) 6). Analysis of adult hippocampus, prefrontal cortex and cerebellum confirmed these observations and a comparison between adult and P6 animals using in situ hybridization indicated that Chordc1 underwent coordinated but altered diurnal changes in mRNA abundance during development. Further, a developmental profile of Chordc1 expression beginning at embryonic day 17 revealed a regional distribution of Chordc1 consistent with its adult pattern. These results suggest that Chordc1 mRNA is under complex and widespread transcriptional regulation during development and implicate Chordc1 in circadian and/or homeostatic mechanisms in mammalian brain.

The zinc-binding protein chordc1 undergoes complex diurnal changes in mRNA expression during mouse brain development. Publishing Authors By Initials

JR Gerstner,CF Landry,

For similar nucleic acids, nucleotides, and nucleosides: nucleic acids: rna: rna, messenger research abstracts see: nucleic acids, nucleotides, and nucleosides: nucleic acids: rna: rna, messenger research

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MEDLINE DATE:

The zinc-binding protein chordc1 undergoes complex diurnal changes in mRNA expression during mouse brain development. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neurochemical research

VOLUME: 32

Page Numbers: 241-50

Journal Abbreviation: Neurochem. Res.

ISSN: 0364-3190

DAY: 26

MONTH: 01

YEAR: 2007

The zinc-binding protein chordc1 undergoes complex diurnal changes in mRNA expression during mouse brain development. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7613461

The zinc-binding protein chordc1 undergoes complex diurnal changes in mRNA expression during mouse brain development. Keywords Mesh Terms:

KEYWORDS: RNA, Messenger

MESH TERMS: metabolism

Chemical & Substance for Abstract: The zinc-binding protein chordc1 undergoes complex diurnal changes in mRNA expression during mouse brain development. Information

Substance Name: RNA, Messenger

Registry Number: 0

Grant and Affiliation Information for The zinc-binding protein chordc1 undergoes complex diurnal changes in mRNA expression during mouse brain development.

AFFILIATION: Neuroscience Training Program and Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719, USA.

Country: United States

AGENCY: United States NCI

GRANT: 5P50 CA084724-04

ACRONYM: CA

MEDLINETA: Neurochem Res

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