The zebrafish embryo as a dynamic model of anoxia tolerance.

The zebrafish embryo as a dynamic model of anoxia tolerance. Research Abstract Details 

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The zebrafish embryo as a dynamic model of anoxia tolerance. Abstract Text:

Developing organisms depend upon a delicate balance in the supply and demand of energy to adapt to variable oxygen availability, although the essential mechanisms determining such adaptation remain elusive. In this study, we examine reversible anoxic arrest and dynamic bioenergetic transitions during zebrafish development. Our data reveal that the duration of anoxic viability corresponds to the developmental stage and anaerobic metabolic rate. Diverse chemical inhibitors of mitochondrial oxidative phosphorylation induce a similar arrest in normoxic embryos, suggesting a pathway responsive to perturbations in aerobic energy production rather than molecular oxygen. Consistent with this concept, arrest is accompanied by rapid activation of the energy-sensing AMP-activated protein kinase pathway, demonstrating a potential link between the sensing of energy status and adaptation to oxygen availability. These observations permit mechanistic insight into energy homeostasis during development that now enable genetic and small molecule screens in this vertebrate model of anoxia tolerance. Developmental Dynamics 237:1780-1788, 2008. (c) 2008 Wiley-Liss, Inc.

The zebrafish embryo as a dynamic model of anoxia tolerance. Publishing Authors By Initials

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The zebrafish embryo as a dynamic model of anoxia tolerance. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Developmental dynamics : an official publication o

VOLUME: 237

Page Numbers: 1780-8

Journal Abbreviation: Dev. Dyn.

ISSN: 1058-8388

DAY: 30

MONTH: Jul

YEAR: 2008

The zebrafish embryo as a dynamic model of anoxia tolerance. Information

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LANGUAGE: eng

NlmUniqueID: 9201927

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Grant and Affiliation Information for The zebrafish embryo as a dynamic model of anoxia tolerance.

AFFILIATION: Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.

Country: United States

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MEDLINETA: Dev Dyn

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